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Molecules 2017, 22(7), 1206; doi:10.3390/molecules22071206

Anti-Inflammatory Triterpene Glycosides from the Roots of Ilex dunniana Levl

1
Key Laboratory of Biotechnology and Bioresources Utilization, Educational of Minister, College of Life Science, Dalian Nationalities University, Dalian 116600, China
2
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
3
Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi 154007, China
4
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
5
Yunnan Branch, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Jing Hong 666100, China
6
Department of Pharmacognosy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 14 June 2017 / Revised: 17 July 2017 / Accepted: 17 July 2017 / Published: 19 July 2017
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Abstract

A new triterpene glycoside ilexdunnoside A (1) and a new sulfated triterpene derivative ilexdunnoside B (2), together with five known analogues 37 were isolated from the roots of Ilex dunniana Levl. The structures were established by NMR spectroscopic analysis and acid hydrolysis. Results of an in vivo study of the biological activity showed that 75% ethanol and n-butanol extracts of the plant displayed anti-inflammatory activities against ear edema in mice, with inhibition rates of 23.5% and 37.5%, respectively, at a dose of 50 mg/kg. Furthermore, Compounds 1, 2 and 3 exhibited moderate indirect inhibitory effects on lipopolysaccharide-induced NO production in BV2 microglial cells in vitro, with IC50 values of 11.60, 12.30 and 9.70 μM, respectively. View Full-Text
Keywords: triterpene glycosides; Ilex dunniana Levl; anti-inflammatory triterpene glycosides; Ilex dunniana Levl; anti-inflammatory
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Shi, Y.-S.; Zhang, Y.; Hu, W.-Z.; Chen, X.; Fu, X.; Lv, X.; Zhang, L.-H.; Zhang, N.; Li, G. Anti-Inflammatory Triterpene Glycosides from the Roots of Ilex dunniana Levl. Molecules 2017, 22, 1206.

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