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Molecules 2017, 22(7), 1136; doi:10.3390/molecules22071136

Cytotoxic Compounds from Aloe megalacantha

1
Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany
2
Department of Chemistry, College of Natural Sciences, Jimma University, P.O. Box 378, 251 Jimma, Ethiopia
*
Authors to whom correspondence should be addressed.
Received: 31 May 2017 / Revised: 27 June 2017 / Accepted: 3 July 2017 / Published: 7 July 2017
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Phytochemical investigation of the ethyl acetate extract of the roots of Aloe megalacantha led to the isolation of four new natural products—1,8-dimethoxynepodinol (1), aloesaponarin III (2), 10-O-methylchrysalodin (3) and methyl-26-O-feruloyl-oxyhexacosanate (4)—along with ten known compounds. All purified metabolites were characterized by NMR, mass spectrometric analyses and comparison with literature data. The isolates were evaluated for their cytotoxic activity against a human cervix carcinoma cell line KB-3-1 and some of them exhibited good activity, with aloesaponarin II (IC50 = 0.98 µM) being the most active compound. View Full-Text
Keywords: Asphodelaceae; Aloe megalacantha; roots; quinone; anthraquinone; cytotoxicity Asphodelaceae; Aloe megalacantha; roots; quinone; anthraquinone; cytotoxicity
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Abdissa, N.; Gohlke, S.; Frese, M.; Sewald, N. Cytotoxic Compounds from Aloe megalacantha. Molecules 2017, 22, 1136.

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