Next Article in Journal
Synthesis and Evaluation of Curcuminoid Analogues as Antioxidant and Antibacterial Agents
Previous Article in Journal
Docosahexaenoic Acid Induces Expression of Heme Oxygenase-1 and NAD(P)H:quinone Oxidoreductase through Activation of Nrf2 in Human Mammary Epithelial Cells
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(6), 968; doi:10.3390/molecules22060968

Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin

1
Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile
2
Escuela de Obstetricia y Puericultura, Facultad de medicina, Campus de la Salud, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2520000, Chile
3
Centro de Investigaciones Biomédicas (CIB), Escuela de Medicina, Universidad de Valparaíso, Av. Hontaneda Nº 2664, Valparaíso 2340000, Chile
4
Departamento De Ciencias Básicas, Campus Fernando May Universidad del Biobío. Avda. Andrés Bello s/n casilla 447, Chillán 3780000, Chile
5
Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Los Laureles s/n, Isla Teja, Valdivia 5090000, Chile
6
Center for Integrative Medicine and Innovative Science (CIMIS), Facultad de Medicina, Universidad Andrés Bello, Santiago 8320000, Chile
*
Author to whom correspondence should be addressed.
Received: 25 May 2017 / Revised: 7 June 2017 / Accepted: 8 June 2017 / Published: 10 June 2017
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [552 KB, uploaded 22 June 2017]   |  

Abstract

An efficient synthesis of a series of 4′-oxyalkyl-isocordoin analogues (28) is reported for the first time. Their structures were confirmed by 1H-NMR, 13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4′-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents. View Full-Text
Keywords: isocordoin; oxyalkyl derivates; anti-oomycete activity; Saprolegnia sp. isocordoin; oxyalkyl derivates; anti-oomycete activity; Saprolegnia sp.
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Escobar, B.; Montenegro, I.; Villena, J.; Werner, E.; Godoy, P.; Olguín, Y.; Madrid, A. Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin. Molecules 2017, 22, 968.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top