Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors
AbstractSecondary sulfonamides (4a–8h) incorporating acetoxybenzamide, triacetoxybenzamide, hydroxybenzamide, and trihydroxybenzamide and possessing thiazole, pyrimidine, pyridine, isoxazole and thiadiazole groups were synthesized. Lactoperoxidase (LPO, E.C.22.214.171.124), as a natural antibacterial agent, is a peroxidase enzyme secreted from salivary, mammary, and other mucosal glands. In the present study, the in vitro inhibitory effects of some secondary sulfonamide derivatives (4a–8h) were examined against LPO. The obtained results reveal that secondary sulfonamide derivatives (4a–8h) are effective LPO inhibitors. The Ki values of secondary sulfonamide derivatives (4a–8h) were found in the range of 1.096 × 10−3 to 1203.83 µM against LPO. However, the most effective inhibition was found for N-(sulfathiazole)-3,4,5-triacetoxybenzamide (6a), with Ki values of 1.096 × 10−3 ± 0.471 × 10−3 µM as non-competitive inhibition. View Full-Text
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Köksal, Z.; Kalin, R.; Camadan, Y.; Usanmaz, H.; Almaz, Z.; Gülçin, İ.; Gokcen, T.; Gören, A.C.; Ozdemir, H. Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors. Molecules 2017, 22, 793.
Köksal Z, Kalin R, Camadan Y, Usanmaz H, Almaz Z, Gülçin İ, Gokcen T, Gören AC, Ozdemir H. Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors. Molecules. 2017; 22(6):793.Chicago/Turabian Style
Köksal, Zeynep; Kalin, Ramazan; Camadan, Yasemin; Usanmaz, Hande; Almaz, Züleyha; Gülçin, İlhami; Gokcen, Taner; Gören, Ahmet C.; Ozdemir, Hasan. 2017. "Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors." Molecules 22, no. 6: 793.
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