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Molecules 2017, 22(5), 802; doi:10.3390/molecules22050802

Optimizing the Readout of Lanthanide-DOTA Complexes for the Detection of Ligand-Bound Copper(I)

EaStCHEM School of Chemistry, The University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh EH9 3FJ, UK
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Author to whom correspondence should be addressed.
Academic Editor: Margaret A. Brimble
Received: 22 March 2017 / Revised: 5 May 2017 / Accepted: 8 May 2017 / Published: 14 May 2017
(This article belongs to the Special Issue Women in Organic Chemistry)
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Abstract

The CuAAC ‘click’ reaction was used to couple alkyne-functionalized lanthanide-DOTA complexes to a range of fluorescent antennae. Screening of the antenna components was aided by comparison of the luminescent output of the resultant sensors using data normalized to account for reaction conversion as assessed by IR. A maximum 82-fold enhanced signal:background luminescence output was achieved using a Eu(III)-DOTA complex coupled to a coumarin-azide, in a reaction which is specific to the presence of copper(I). This optimized complex provides a new lead design for lanthanide-DOTA complexes which can act as irreversible ‘turn-on’ catalytic sensors for the detection of ligand-bound copper(I). View Full-Text
Keywords: CuAAC click reaction; DOTA complexes; luminescence; Cu(I) sensor; picolinyl azides; coumarin azides CuAAC click reaction; DOTA complexes; luminescence; Cu(I) sensor; picolinyl azides; coumarin azides
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Hanna, J.R.; Allan, C.; Lawrence, C.; Meyer, O.; Wilson, N.D.; Hulme, A.N. Optimizing the Readout of Lanthanide-DOTA Complexes for the Detection of Ligand-Bound Copper(I). Molecules 2017, 22, 802.

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