Optimizing the Readout of Lanthanide-DOTA Complexes for the Detection of Ligand-Bound Copper(I)
AbstractThe CuAAC ‘click’ reaction was used to couple alkyne-functionalized lanthanide-DOTA complexes to a range of fluorescent antennae. Screening of the antenna components was aided by comparison of the luminescent output of the resultant sensors using data normalized to account for reaction conversion as assessed by IR. A maximum 82-fold enhanced signal:background luminescence output was achieved using a Eu(III)-DOTA complex coupled to a coumarin-azide, in a reaction which is specific to the presence of copper(I). This optimized complex provides a new lead design for lanthanide-DOTA complexes which can act as irreversible ‘turn-on’ catalytic sensors for the detection of ligand-bound copper(I). View Full-Text
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Hanna, J.R.; Allan, C.; Lawrence, C.; Meyer, O.; Wilson, N.D.; Hulme, A.N. Optimizing the Readout of Lanthanide-DOTA Complexes for the Detection of Ligand-Bound Copper(I). Molecules 2017, 22, 802.
Hanna JR, Allan C, Lawrence C, Meyer O, Wilson ND, Hulme AN. Optimizing the Readout of Lanthanide-DOTA Complexes for the Detection of Ligand-Bound Copper(I). Molecules. 2017; 22(5):802.Chicago/Turabian Style
Hanna, Jill R.; Allan, Christopher; Lawrence, Charlotte; Meyer, Odile; Wilson, Neil D.; Hulme, Alison N. 2017. "Optimizing the Readout of Lanthanide-DOTA Complexes for the Detection of Ligand-Bound Copper(I)." Molecules 22, no. 5: 802.
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