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Molecules 2017, 22(5), 779; doi:10.3390/molecules22050779

Chemical Composition of Laurencia obtusa Extract and Isolation of a New C15-Acetogenin

1
Université de Corse-CNRS, UMR 6134 SPE, Equipe Chimie et Biomasse, Route des Sanguinaires, 20000 Ajaccio, France
2
CNC.IBILI/Faculty of Pharmacy, University of Coimbra, Health Sciences Campus, Azinhaga de S. Comba, 3000-548 Coimbra, Portugal
3
Escola Superior de Saúde Dr. Lopes Dias, Instituto Politécnico de Castelo Branco, Campus da Talagueira, 6000-767 Castelo Branco, Portugal
4
Plateforme d’Ingénierie et d’Analyses Moléculaires, Université d’Angers, UFR Sciences, 49000 Angers, France
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 11 April 2017 / Revised: 27 April 2017 / Accepted: 6 May 2017 / Published: 11 May 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [715 KB, uploaded 15 May 2017]   |  

Abstract

A new C15-acetogenin, sagonenyne (20), exhibiting an unusual single tetrahydropyran ring was isolated from an ethyl acetate extract of Laurencia obtusa collected on the Corsican coastline. Its structure was established by detailed NMR spectroscopic analysis, mass spectrometry, and comparison with literature data. Twenty-three known compounds were identified in the same extract by means of column chromatography steps, using a 13C-NMR computer aided method developed in our laboratory. In addition to sesquiterpenes, which represent the main chemical class of this extract, diterpenes, sterols, and C15-acetogenins were identified. The crude extract was submitted to a cytotoxicity assay and was particularly active against THP-1 cells, a human leukemia monocytic cell line. View Full-Text
Keywords: Laurencia obtusa; 13C-NMR; corsica; cytotoxic activity; sagonenyne Laurencia obtusa; 13C-NMR; corsica; cytotoxic activity; sagonenyne
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MDPI and ACS Style

Esselin, H.; Sutour, S.; Liberal, J.; Cruz, M.T.; Salgueiro, L.; Siegler, B.; Freuze, I.; Castola, V.; Paoli, M.; Bighelli, A.; Tomi, F. Chemical Composition of Laurencia obtusa Extract and Isolation of a New C15-Acetogenin. Molecules 2017, 22, 779.

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