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Molecules 2017, 22(5), 695; doi:10.3390/molecules22050695

Base-Promoted Synthesis of β-Substituted-Tryptophans via a Simple and Convenient Three-Component Condensation of Nickel(II) Glycinate

1,2,†
,
1,3,†
,
3
,
3
,
2,3,* and 1,*
1
West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China
2
Department of Medicinal Chemistry, School of Pharmacy, Chengdu Medical College, Chengdu 610500, Sichuan, China
3
Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
These authors contributed equally.
*
Authors to whom correspondence should be addressed.
Academic Editor: Artur M. S. Silva
Received: 6 March 2017 / Revised: 24 April 2017 / Accepted: 24 April 2017 / Published: 27 April 2017
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [1550 KB, uploaded 27 April 2017]   |  

Abstract

A three-component reaction of nickel(II) glycinate was conducted for the convenient synthesis of β-substituted-tryptophans. The reaction worked smoothly under mild conditions and the procedure was simple and easy to handle. View Full-Text
Keywords: three-component reaction; nickel(II) glycinate; β-substituted-tryptophans; convenient three-component reaction; nickel(II) glycinate; β-substituted-tryptophans; convenient
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Zhou, R.; Pan, Z.; Zhang, Y.; Wu, F.; Jiang, Q.; Guo, L. Base-Promoted Synthesis of β-Substituted-Tryptophans via a Simple and Convenient Three-Component Condensation of Nickel(II) Glycinate. Molecules 2017, 22, 695.

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