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Molecules 2017, 22(4), 676; doi:10.3390/molecules22040676

Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration

Department of Surgery, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
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Author to whom correspondence should be addressed.
Academic Editors: Francisco Ciruela and Eddy Sotelo
Received: 25 March 2017 / Revised: 21 April 2017 / Accepted: 21 April 2017 / Published: 23 April 2017
(This article belongs to the Special Issue Adenosine Receptors)
View Full-Text   |   Download PDF [5360 KB, uploaded 23 April 2017]   |  

Abstract

The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are predominantly expressed in the brain. Whereas the A2AR has been implicated in normal aging and enhancing neurotoxicity in multiple neurodegenerative diseases, the inhibitory A1R has traditionally been ascribed to have a neuroprotective function in various brain insults. This review provides a summary of the emerging role of prolonged A1R signaling and its potential cross-talk with A2AR in the cellular basis for increased neurotoxicity in neurodegenerative disorders. This A1R signaling enhances A2AR-mediated neurodegeneration, and provides a platform for future development of neuroprotective agents in stroke, Parkinson’s disease and epilepsy. View Full-Text
Keywords: adenosine receptor cross-talk; A1R-mediated neurotoxicity; neurodegenerative diseases adenosine receptor cross-talk; A1R-mediated neurotoxicity; neurodegenerative diseases
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Stockwell, J.; Jakova, E.; Cayabyab, F.S. Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration. Molecules 2017, 22, 676.

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