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Molecules 2017, 22(4), 646; doi:10.3390/molecules22040646

Metajapogenins A–C, Pregnane Steroids from Shells of Metaplexis japonica

School of Pharmacy, Qingdao University, Qingdao 266021, Shandong, China
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Academic Editor: Vassilios Roussis
Received: 16 March 2017 / Revised: 13 April 2017 / Accepted: 15 April 2017 / Published: 17 April 2017
(This article belongs to the Section Natural Products)
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Abstract

Phytochemical investigation of the shells of Metaplexis japonica (Thunb.) Makino, belonging to the family of Apocynaceae, afforded three new pregnane steroids, metajapogenins A–C, along with three known compounds. The structures of the new compounds were elucidated as 12β,14β,17β-trihydroxypregna-3,5-dien-7,20-dione, 12β,14β,17β,20β-tetrahydroxypregna-3,5-dien-7-one; 3β,12β,14β,17β-tetrahydroxypregn-5-ene-7,20-dione on the basis of extensive spectroscopic evidence derived from 1D; 2D-NMR experiments and mass spectrometry. The known compounds included pergularin; 12-O-acetylpergularin; and pergularin-3-O-β-d-oleandropyranose; which were identified for the first time in the shells of M. japonica. View Full-Text
Keywords: Metaplexis japonica (Thunb.) Makino; Apocynaceae; pregnane steroid; metajapogenins A–C Metaplexis japonica (Thunb.) Makino; Apocynaceae; pregnane steroid; metajapogenins A–C
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MDPI and ACS Style

Yao, H.-L.; Liu, Y.; Liu, X.-H.; Gao, H.; Liu, K.; Shao, Y.-L.; Fang, X.-Y.; Wang, W. Metajapogenins A–C, Pregnane Steroids from Shells of Metaplexis japonica. Molecules 2017, 22, 646.

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