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Molecules 2017, 22(4), 642; doi:10.3390/molecules22040642

Anti-Proliferative Effect of Triterpenoidal Glycosides from the Roots of Anemone vitifolia through a Pro-Apoptotic Way

1
Key Laboratory of Hui Medicine Modernization, Ministry of Education, Ningxia Medical University Pharmacy College, Yinchuan 750004, China
2
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
These authors contributed to the paper equally.
*
Authors to whom correspondence should be addressed.
Academic Editor: Fernando Albericio
Received: 10 March 2017 / Revised: 12 April 2017 / Accepted: 13 April 2017 / Published: 17 April 2017
View Full-Text   |   Download PDF [2128 KB, uploaded 17 April 2017]   |  

Abstract

A cytotoxicity-guided phytochemical investigation of Anemone vitifolia roots led to the isolation of six oleanane saponins (16), which were reported from the species for the first time. Their structures were determined by comparing its MS and NMR data with those in literature. Compounds 14 showed significant inhibitory effects on the proliferation of hepatocellular carcinoma HepG2 cells with IC50 values ranging from 2.0 to 8.5 μM, compared to positive control methotrexate with IC50 value of 15.8 μM. Flow cytometry analysis revealed that compounds 14 exerted anti-proliferative effects through a pro-apoptotic way of hepatocellular carcinoma cells. View Full-Text
Keywords: Anemone vitifolia; cytotoxicity-guided fractionation; oleanane saponin; anti-proliferation; apoptosis; HepG2 Anemone vitifolia; cytotoxicity-guided fractionation; oleanane saponin; anti-proliferation; apoptosis; HepG2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bai, C.; Ye, Y.; Feng, X.; Bai, R.; Han, L.; Zhou, X.; Yang, X.; Tu, P.; Chai, X. Anti-Proliferative Effect of Triterpenoidal Glycosides from the Roots of Anemone vitifolia through a Pro-Apoptotic Way. Molecules 2017, 22, 642.

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