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Molecules 2017, 22(4), 604; doi:10.3390/molecules22040604

Structural Characterization and Antifungal Studies of Zinc-Doped Hydroxyapatite Coatings

1
National Institute of Materials Physics, Atomistilor Street, No. 105 bis, P.O. Box MG 07, 077125 Magurele, Romania
2
Emergency Hospital Floreasca Bucharest, 8 Calea Floresca, Sector 1, 014461 Bucharest, Romania
3
Surgery Department, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Sector 5, 050474 Bucharest, Romania
4
HORIBA Jobin Yvon S.A.S., 6-18, rue du Canal, 91165 Longjumeau CEDEX, France
*
Author to whom correspondence should be addressed.
Academic Editors: Krasimir Vasilev, Alex Cavallaro and Peter Zilm
Received: 6 March 2017 / Revised: 31 March 2017 / Accepted: 7 April 2017 / Published: 9 April 2017
(This article belongs to the Special Issue Antibacterial Materials and Coatings)
View Full-Text   |   Download PDF [16915 KB, uploaded 9 April 2017]   |  

Abstract

The present study is focused on the synthesis, characterization and antifungal evaluation of zinc-doped hydroxyapatite (Zn:HAp) coatings. The Zn:HAp coatings were deposited on a pure Si (Zn:HAp_Si) and Ti (Zn:HAp_Ti) substrate by a sol-gel dip coating method using a zinc-doped hydroxyapatite nanogel. The nature of the crystal phase was determined by X-ray diffraction (XRD). The crystalline phase of the prepared Zn:HAp composite was assigned to hexagonal hydroxyapatite in the P63/m space group. The colloidal properties of the resulting Zn:HAp (xZn = 0.1) nanogel were analyzed by Dynamic Light Scattering (DLS) and zeta potential. Scanning Electron Microscopy (SEM) was used to investigate the morphology of the zinc-doped hydroxyapatite (Zn:HAp) nanogel composite and Zn:HAp coatings. The elements Ca, P, O and Zn were found in the Zn:HAp composite. According to the EDX results, the degree of Zn substitution in the structure of Zn:HAp composite was 1.67 wt%. Moreover, the antifungal activity of Zn:HAp_Si and Zn:HAp_Ti against Candida albicans (C. albicans) was evaluated. A decrease in the number of surviving cells was not observed under dark conditions, whereas under daylight and UV light illumination a major decrease in the number of surviving cells was observed. View Full-Text
Keywords: zinc; hydroxyapatite; C. albicans; thin layer zinc; hydroxyapatite; C. albicans; thin layer
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MDPI and ACS Style

Iconaru, S.L.; Prodan, A.M.; Buton, N.; Predoi, D. Structural Characterization and Antifungal Studies of Zinc-Doped Hydroxyapatite Coatings. Molecules 2017, 22, 604.

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