Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer
AbstractEvidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B12-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H2S), hydrosulfide derivatives of cobalamins, autoxidation of hydrosulfide radical, radical S-adenosylmethionine methyl transfer (RSMT), and methionine synthase (MS). Then, new reaction mechanisms for B12-dependent methyl group transfer are proposed; the mechanisms are facile and overcome difficulties that existed in previously-accepted mechanisms. Finally, the theory is applied to the effect of S°/H2S in nerve tissue involving the “hypomethylation theory” that was proposed 50 years ago to explain the neuropathology resulting from deficiency of vitamin B12 or folic acid. The conclusions are consistent with emerging evidence that sulfane sulfur/hydrogen sulfide may be beneficial in treating Alzheimer’s disease. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Toohey, J.I. Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer. Molecules 2017, 22, 582.
Toohey JI. Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer. Molecules. 2017; 22(4):582.Chicago/Turabian Style
Toohey, John I. 2017. "Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer." Molecules 22, no. 4: 582.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.