Next Article in Journal
Antioxidant Properties and Oxidative Transformation of Different Chromone Derivatives
Next Article in Special Issue
The Hydrogen Sulfide-Vitamin B12-Folic Acid Axis: An Intriguing Issue in Chronic Kidney Disease. A Comment on Toohey JI: “Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer”. Molecules 2017, 22, 582, pii: E582
Previous Article in Journal
Strengthening Triterpene Saponins Biosynthesis by Over-Expression of Farnesyl Pyrophosphate Synthase Gene and RNA Interference of Cycloartenol Synthase Gene in Panax notoginseng Cells
Previous Article in Special Issue
Hydrogen Sulphide Production in Healthy and Ulcerated Gastric Mucosa of Rats
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessHypothesis
Molecules 2017, 22(4), 582; doi:10.3390/molecules22040582

Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer

Cytoregulation Research, Elgin, ON K0G1E0, Canada
Academic Editors: Noriyuki Nagahara and Maria Wrobel
Received: 6 February 2017 / Revised: 22 March 2017 / Accepted: 30 March 2017 / Published: 5 April 2017
(This article belongs to the Special Issue Sulfur Atom: Element for Adaptation to an Oxidative Environment 2016)
View Full-Text   |   Download PDF [4651 KB, uploaded 7 April 2017]   |  

Abstract

Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B12-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H2S), hydrosulfide derivatives of cobalamins, autoxidation of hydrosulfide radical, radical S-adenosylmethionine methyl transfer (RSMT), and methionine synthase (MS). Then, new reaction mechanisms for B12-dependent methyl group transfer are proposed; the mechanisms are facile and overcome difficulties that existed in previously-accepted mechanisms. Finally, the theory is applied to the effect of S°/H2S in nerve tissue involving the “hypomethylation theory” that was proposed 50 years ago to explain the neuropathology resulting from deficiency of vitamin B12 or folic acid. The conclusions are consistent with emerging evidence that sulfane sulfur/hydrogen sulfide may be beneficial in treating Alzheimer’s disease. View Full-Text
Keywords: sulfane sulfur; hydrogen sulfide; methylation; radical S-adenosylmethionine methyl transferases; methionine synthase; cobalamin; viscose dialysis tubing; methionine auxotrophy; hypomethylation; dementia; Alzheimer’s disease sulfane sulfur; hydrogen sulfide; methylation; radical S-adenosylmethionine methyl transferases; methionine synthase; cobalamin; viscose dialysis tubing; methionine auxotrophy; hypomethylation; dementia; Alzheimer’s disease
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Toohey, J.I. Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer. Molecules 2017, 22, 582.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top