Next Article in Journal
Sulfur-Doped Carbon Nitride Polymers for Photocatalytic Degradation of Organic Pollutant and Reduction of Cr(VI)
Next Article in Special Issue
Recent Advances in Cyanamide Chemistry: Synthesis and Applications
Previous Article in Journal
Self-Organized TiO2–MnO2 Nanotube Arrays for Efficient Photocatalytic Degradation of Toluene
Previous Article in Special Issue
Chemical Synthesis and Characterization of an Equinatoxin II(1–85) Analogue
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessFeature PaperReview
Molecules 2017, 22(4), 574; doi:10.3390/molecules22040574

Direct Substitution of Alcohols in Pure Water by Brønsted Acid Catalysis

Laboratorio de Organocatálisis Asimétrica, Departamento de Química Orgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH) CSIC-Universidad de Zaragoza, C/Pedro Cerbuna 12, Zaragoza 50009, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Margaret A. Brimble
Received: 8 March 2017 / Revised: 29 March 2017 / Accepted: 30 March 2017 / Published: 1 April 2017
(This article belongs to the Special Issue Women in Organic Chemistry)
View Full-Text   |   Download PDF [4732 KB, uploaded 1 April 2017]   |  

Abstract

With the increasing concern for sustainability, the use of environmentally friendly media to perform chemical processes has attracted the attention of many research groups. Among them, the use of water, as the unique solvent for reactions, is currently an active area of research. One process of particular interest is the direct nucleophilic substitution of an alcohol avoiding its preliminary transformation into a good leaving group, since one of the by-products in this approach would be water. The direct substitution of allylic, benzylic, and tertiary alcohols has been achieved through SN1-type reactions with catalytic amounts of Brønsted or Lewis acids; however, organic solvents are often required. In this review, the pioneering SN1 approaches performed in pure water and in the absence of a metal based Lewis acid are compiled and discussed. View Full-Text
Keywords: alcohol; non-catalyzed; organocatalysis; SN1; water alcohol; non-catalyzed; organocatalysis; SN1; water
Figures

Scheme 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ortiz, R.; Herrera, R.P. Direct Substitution of Alcohols in Pure Water by Brønsted Acid Catalysis. Molecules 2017, 22, 574.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top