Next Article in Journal
Biodegradable Poly(Amino Ester) with Aromatic Backbone as Efficient Nonviral Gene Delivery Vectors
Next Article in Special Issue
Phytochemical Profiles and Antimicrobial Activities of Allium cepa Red cv. and A. sativum Subjected to Different Drying Methods: A Comparative MS-Based Metabolomics
Previous Article in Journal
Optimizing Sample Size to Assess the Genetic Diversity in Common Vetch (Vicia sativa L.) Populations Using Start Codon Targeted (SCoT) Markers
Previous Article in Special Issue
Selenium and Sulfur to Produce Allium Functional Crops
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview
Molecules 2017, 22(4), 570; doi:10.3390/molecules22040570

Chemical and Biological Properties of S-1-Propenyl-ʟ-Cysteine in Aged Garlic Extract

Drug Discovery Laboratory, Wakunaga Pharmaceutical Co., Ltd., Hiroshima 739-1195, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Martin C.H. Gruhlke and Alan J. Slusarenko
Received: 7 February 2017 / Revised: 27 March 2017 / Accepted: 27 March 2017 / Published: 31 March 2017
(This article belongs to the Special Issue The Chemistry of Alliums)
View Full-Text   |   Download PDF [1778 KB, uploaded 6 April 2017]   |  

Abstract

S-1-Propenyl-ʟ-cysteine (S1PC) is a stereoisomer of S-1-Propenyl-ʟ-cysteine (SAC), an important sulfur-containing amino acid that plays a role for the beneficial pharmacological effects of aged garlic extract (AGE). The existence of S1PC in garlic preparations has been known since the 1960’s. However, there was no report regarding the biological and/or pharmacological activity of S1PC until 2016. Recently, we performed a series of studies to examine the chemical, biological, pharmacological and pharmacokinetic properties of S1PC, and obtained some interesting results. S1PC existed only in trace amounts in raw garlic, but its concentration increased almost up to the level similar of SAC through aging process of AGE. S1PC showed immunomodulatory effects in vitro and in vivo, and reduced blood pressure in a hypertensive animal model. A pharmacokinetic study revealed that S1PC was readily absorbed after oral administration in rats and dogs with bioavailability of 88–100%. Additionally, S1PC had little inhibitory influence on human cytochrome P450 activities, even at a concentration of 1 mM. Based on these findings, S1PC was suggested to be another important, pharmacologically active and safe component of AGE similar to SAC. In this review, we highlight some results from recent studies on S1PC and discuss the potential medicinal value of S1PC. View Full-Text
Keywords: garlic (Allium sativum L.); S-1-propenyl-ʟ-cysteine; processing; aged garlic extract; organic synthesis; isomerization; immunomodulatory effect; antihypertension; pharmacokinetics; drug-drug interactions garlic (Allium sativum L.); S-1-propenyl-ʟ-cysteine; processing; aged garlic extract; organic synthesis; isomerization; immunomodulatory effect; antihypertension; pharmacokinetics; drug-drug interactions
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kodera, Y.; Ushijima, M.; Amano, H.; Suzuki, J.-I.; Matsutomo, T. Chemical and Biological Properties of S-1-Propenyl-ʟ-Cysteine in Aged Garlic Extract. Molecules 2017, 22, 570.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top