Neoantimycins A and B, Two Unusual Benzamido Nine-Membered Dilactones from Marine-Derived Streptomyces antibioticus H12-15
AbstractAn actinomycete strain (H12-15) isolated from a sea sediment in a mangrove district was identified as Streptomyces antibioticus on the basis of 16S rDNA gene sequence analysis as well as the investigation of its morphological, physiological, and biochemical characteristics. Two novel benzamido nonacyclic dilactones, namely neoantimycins A (1) and B (2), together with the known antimycins A1ab (3a,b), A2a (4), and A9 (5), were isolated from the culture broth of this strain. Compounds 1 and 2 are the first natural modified ATNs with an unusual benzamide unit. The structures of these new compounds, including their absolute configuration, were established on the basis of HRMS, NMR spectroscopic data, and quantum chemical ECD calculations. Their cytotoxicities against human breast adenocarcinoma cell line MCF-7, the human glioblastoma cell line SF-268, and the human lung cancer cell line NCI-H460 were also tested. All compounds exhibited mild cytotoxic activity. However, Compounds 1 and 2 showed no activity against C. albicans at the test concentration of 1 mg/mL via paper disc diffusion, while the known antimycins showed obvious antifungal activity. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 2215 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Hu, C.; Zhou, S.-W.; Chen, F.; Zheng, X.-H.; Shen, H.-F.; Lin, B.-R.; Zhou, G.-X. Neoantimycins A and B, Two Unusual Benzamido Nine-Membered Dilactones from Marine-Derived Streptomyces antibioticus H12-15. Molecules 2017, 22, 557.
Hu C, Zhou S-W, Chen F, Zheng X-H, Shen H-F, Lin B-R, Zhou G-X. Neoantimycins A and B, Two Unusual Benzamido Nine-Membered Dilactones from Marine-Derived Streptomyces antibioticus H12-15. Molecules. 2017; 22(4):557.Chicago/Turabian Style
Hu, Chen; Zhou, Shi-Wen; Chen, Fang; Zheng, Xin-Heng; Shen, Hui-Fang; Lin, Bi-Run; Zhou, Guang-Xiong. 2017. "Neoantimycins A and B, Two Unusual Benzamido Nine-Membered Dilactones from Marine-Derived Streptomyces antibioticus H12-15." Molecules 22, no. 4: 557.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.