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Molecules 2017, 22(4), 515; doi:10.3390/molecules22040515

Phenolic Compounds from the Rhizomes of Smilax china L. and Their Anti-Inflammatory Activity

1
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
2
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
3
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 20 February 2017 / Revised: 17 March 2017 / Accepted: 18 March 2017 / Published: 3 April 2017
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [736 KB, uploaded 3 April 2017]   |  

Abstract

A new triflavanoid, kandelin B-5 (1), was isolated from the rhizomes of Smilax china L., together with six known phenylpropanoid substituted flavan-3-ols (27), nine flavonoids (816), two stilbenoids (17, 18), and two other compounds (19, 20). The structure of compound 1 was determined on the basis of 1D, 2D NMR and HR-ESI-MS data, as well as chemical method. Compounds 25, 812, 15, 17, and 19 were evaluated for anti-inflammatory activity. Only compounds 10, 15 and 17 showed slightly IL-1β expression inhibitory activities on LPS induced THP-1 cells, with inhibition rate of 15.8%, 37.3%, and 35.8%, respectively, at concentration of 50 μg/mL. View Full-Text
Keywords: Smilax china; phenolic compounds; anti-inflammatory activity Smilax china; phenolic compounds; anti-inflammatory activity
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Zhong, C.; Hu, D.; Hou, L.-B.; Song, L.-Y.; Zhang, Y.-J.; Xie, Y.; Tian, L.-W. Phenolic Compounds from the Rhizomes of Smilax china L. and Their Anti-Inflammatory Activity. Molecules 2017, 22, 515.

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