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Molecules 2017, 22(3), 504; doi:10.3390/molecules22030504

The Anti-Allergic Rhinitis Effect of Traditional Chinese Medicine of Shenqi by Regulating Mast Cell Degranulation and Th1/Th2 Cytokine Balance

1
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
2
Department of Liver disease, Army General Hospital of PLA, Beijing 100700, China
3
Department of Pharmacy, Changji Vocational and Technical College, Changji 831100, China
4
Xinjiang Jinshikang Pharmaceutical Co., Ltd., Urumchi 830000, China
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 21 February 2017 / Revised: 21 March 2017 / Accepted: 21 March 2017 / Published: 22 March 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2671 KB, uploaded 22 March 2017]   |  

Abstract

Shenqi is a traditional Chinese polyherbal medicine has been widely used for the treatment of allergic rhinitis (AR). The aim of this study was to investigate the anti-allergic rhinitis activity of Shenqi and explore its underlying molecular mechanism. Ovalbumin (OVA)-induced allergic rhinitis rat model was used to evaluate the anti-allergic rhinitis effect of Shenqi. The effect of Shenqi on IgE-mediated degranulation was measured using rat basophilic leukemia (RBL-2H3) cells. Primary spleen lymphocytes were isolated to investigate the anti-allergic mechanism of Shenqi by detecting the expression of transcription factors via Western blot and the level of cytokines (IL-4 and IFN-γ) via ELISA. In OVA-induced AR rat models, Shenqi relieved the allergic rhinitis symptoms, inhibited the histopathological changes of nasal mucosa, and reduced the levels of IL-4 and IgE. The results from the in vitro study certified that Shenqi inhibited mast cell degranulation. Furthermore, the results of GATA3, T-bet, p-STAT6, and SOCS1 expression and production of IFN-γ and IL-4 demonstrated that Shenqi balanced the ratio of Th1/Th2 (IFN-γ/IL-4) in OVA-stimulated spleen lymphocytes. In conclusion, these results suggest that Shenqi exhibits an obvious anti-allergic effect by suppressing the mast cell-mediated allergic response and by improving the imbalance of Th1/Th2 ratio in allergic rhinitis. View Full-Text
Keywords: allergic rhinitis; anti-allergic activity; Shenqi; degranulation; Th1/Th2 balance allergic rhinitis; anti-allergic activity; Shenqi; degranulation; Th1/Th2 balance
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Shao, Y.-Y.; Zhou, Y.-M.; Hu, M.; Li, J.-Z.; Chen, C.-J.; Wang, Y.-J.; Shi, X.-Y.; Wang, W.-J.; Zhang, T.-T. The Anti-Allergic Rhinitis Effect of Traditional Chinese Medicine of Shenqi by Regulating Mast Cell Degranulation and Th1/Th2 Cytokine Balance. Molecules 2017, 22, 504.

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