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Molecules 2017, 22(3), 498; doi:10.3390/molecules22030498

The Effects of Sweet Foods on the Pharmacokinetics of Glycyrrhizic Acid by icELISA

1
School of Basic Medical Sciences, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China
2
Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China
3
School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China
*
Author to whom correspondence should be addressed.
Academic Editor: Stefan Berger
Received: 16 February 2017 / Revised: 13 March 2017 / Accepted: 16 March 2017 / Published: 21 March 2017
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Abstract

The effect of sweet foods, such as honey, was investigated from the perspective of pharmacokinetics on the absorption of glycyrrhizic acid (GA). Due to the unique properties of indirect competitive enzyme-linked immunosorbent assay (icELISA), namely, its: specificity, sensitivity, repeatability, simple pretreatment of samples, fast and simple operation, and because it is economic and non-polluting, it has received increased attention. In this study, we used the advantages of this method to see how honey affected the pharmacokinetics of GA. The effects of honey on the pharmacokinetics of GA by ELISA were investigated for the first time. The results indicate that honey can postpone the peak concentration of GA in mouse blood, and this effect correlates well with fructose. As a representative of sweet foods, the result provides the valuable information that honey, or fructose, may act as sustained-releasing drugs in clinical scenarios; and that sweet foods may have some influences on drugs when taken together. View Full-Text
Keywords: glycyrrhizic acid; icELISA; pharmacokinetics; sweet foods glycyrrhizic acid; icELISA; pharmacokinetics; sweet foods
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Jiang, B.; Qu, H.; Kong, H.; Zhang, Y.; Liu, S.; Cheng, J.; Yan, X.; Zhao, Y. The Effects of Sweet Foods on the Pharmacokinetics of Glycyrrhizic Acid by icELISA. Molecules 2017, 22, 498.

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