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Molecules 2017, 22(3), 367; doi:10.3390/molecules22030367

Chemical Composition, In Vitro Antimicrobial, Free-Radical-Scavenging and Antioxidant Activities of the Essential Oil of Leucas inflata Benth

Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Department of Pharmacognosy, Faculty of Pharmacy, Sana’a-University, P.O. Box 33039, Sana’a, Yemen
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Author to whom correspondence should be addressed.
Academic Editor: Fernando Albericio
Received: 8 February 2017 / Accepted: 21 February 2017 / Published: 27 February 2017
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The essential oil of Leucas inflata Balf.f. (Lamiaceae), collected in Yemen, was analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) techniques. Forty-three components were recognized, representing 89.2% of the total oil. The L. inflata volatile oil was found to contain a high percentage of aliphatic acids (51.1%). Hexadecanoic acid (32.8%) and n-dodecanoic acid (7.8%) were identified as the major compounds. Oxygenated monoterpenes were distinguished as the second significant group of constituents (16.0%). Camphor (6.1%) and linalool (3.2%) were found to be the main components among the oxygenated monoterpenes. In addition, the volatile oil was assessed for its antimicrobial activity against four bacterial strains and one yeast species using broth micro-dilution assay for minimum inhibitory concentrations (MIC). In addition, antioxidant activity was measured utilizing the anti-radical activity of the sable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and β-Carotene-linoleic acid assays. The oil of L. inflata showed an excellent antibacterial activity against only the tested Gram-positive bacteria with a MIC-value of 0.81 mg/mL. Furthermore, the oil demonstrated, at a concentration of 1 mg/mL, a weak to moderate antiradical and antioxidant activity of 38% and 32%, respectively. View Full-Text
Keywords: Leucas inflata; GC; GC/MS; essential oil; antimicrobial; antioxidant Leucas inflata; GC; GC/MS; essential oil; antimicrobial; antioxidant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mothana, R.A.; Noman, O.M.; Al-Sheddi, E.S.; Khaled, J.M.; Al-Said, M.S.; Al-Rehaily, A.J. Chemical Composition, In Vitro Antimicrobial, Free-Radical-Scavenging and Antioxidant Activities of the Essential Oil of Leucas inflata Benth. Molecules 2017, 22, 367.

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