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Molecules 2017, 22(3), 349; doi:10.3390/molecules22030349

Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules

Department Chemie, Technische Universität München, Lichtenbergstr. 4, Garching 85747, Germany
Academic Editor: Roman Dembinski
Received: 21 December 2016 / Revised: 7 February 2017 / Accepted: 13 February 2017 / Published: 25 February 2017
(This article belongs to the Section Organic Synthesis)

Abstract

Several novel methods, catalysts and reagents have been developed to improve organic synthesis. Synergistic effects between reactions, reagents and catalysts can lead to minor heats of reaction and occur as an inherent result of multicomponent reactions (MCRs) and their extensions. They enable syntheses to be performed at a low energy level and the number of synthesis steps to be drastically reduced in comparison with ‘classical’ two-component reactions, fulfilling the rules of Green Chemistry. The very high potential for variability, diversity and complexity of MCRs additionally generates an extremely diverse range of products, thus bringing us closer to the aim of being able to produce tailor-made and extremely low-cost materials, drugs and compound libraries. View Full-Text
Keywords: multicomponents; MCR; post condensation modification/cyclisation PCM/PCC; MFCR; multifunction catalysis; variability; diversity; complexity; efficiency of synthesis multicomponents; MCR; post condensation modification/cyclisation PCM/PCC; MFCR; multifunction catalysis; variability; diversity; complexity; efficiency of synthesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Eckert, H. Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)—The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules. Molecules 2017, 22, 349.

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