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Molecules 2017, 22(3), 346;

Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents

Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah-Al-mukkarramah 21514, Saudi Arabia
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh-11451, Saudi Arabia
Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah B.O. 208203, Saudi Arabia
Authors to whom correspondence should be addressed.
Academic Editors: Panayiotis A. Koutentis and Derek J. McPhee
Received: 1 January 2017 / Revised: 19 February 2017 / Accepted: 21 February 2017 / Published: 23 February 2017
(This article belongs to the Section Organic Chemistry)
View Full-Text   |   Download PDF [1157 KB, uploaded 24 February 2017]   |  


In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation. Their pharmacological activity toward bacteria and fungi inhibition was screened and compared to the references Chloramphenicol and Trimethoprim/sulphamethoxazole. The antimicrobial results of the investigated compounds revealed promising results and some derivatives have activities similar to the references used. View Full-Text
Keywords: thiophenes; pyrazoles; thiazoles; antimicrobial activity; microwave irradiation thiophenes; pyrazoles; thiazoles; antimicrobial activity; microwave irradiation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gomha, S.M.; Farghaly, T.A.; Mabkhot, Y.N.; Zayed, M.E.M.; Mohamed, A.M.G. Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents. Molecules 2017, 22, 346.

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