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Molecules 2017, 22(2), 263; doi:10.3390/molecules22020263

A Comparative Analysis of the Chemical Composition, Anti-Inflammatory, and Antinociceptive Effects of the Essential Oils from Three Species of Mentha Cultivated in Romania

1
Department of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania
2
Department of Analytical Chemistry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania
3
Department of Drug Analysis, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania
4
Department of Bromatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania
5
Department of Pharmaceutical Botany, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400337, Romania
6
SC Fares Biovital Laboratories SRL, Orastie 335700, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 15 November 2016 / Revised: 30 January 2017 / Accepted: 6 February 2017 / Published: 10 February 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [232 KB, uploaded 10 February 2017]

Abstract

This work was aimed at correlating the chemotype of three Mentha species cultivated in Romania with an in vivo study of the anti-inflammatory and antinociceptive effects of essential oils. The selected species were Mentha piperita L. var. pallescens (white peppermint), Mentha spicata L. subsp. crispata (spearmint), and Mentha suaveolens Ehrh. (pineapple mint). Qualitative and quantitative analysis of the essential oils isolated from the selected Mentha species was performed by gas chromatography coupled with mass spectrometry (GC-MS). The anti-inflammatory activity of the essential oils was determined by the rat paw edema test induced by λ-carrageenan. The antinociceptive effect of the essential oils was evaluated by the writhing test in mice, using 1% (v/v) acetic acid solution administered intraperitonealy and by the hot plate test in mice. The results showed a menthol chemotype for M. piperita pallescens, a carvone chemotype for M. spicata, and a piperitenone oxide chemotype for M. suaveolens. The essential oil from M. spicata L. (EOMSP) produced statistically significant and dose-dependent anti-inflammatory and antinociceptive effects. View Full-Text
Keywords: Mentha spp.; menthol; carvone; piperitenone oxide; anti-inflammatory; antinociceptive Mentha spp.; menthol; carvone; piperitenone oxide; anti-inflammatory; antinociceptive
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mogosan, C.; Vostinaru, O.; Oprean, R.; Heghes, C.; Filip, L.; Balica, G.; Moldovan, R.I. A Comparative Analysis of the Chemical Composition, Anti-Inflammatory, and Antinociceptive Effects of the Essential Oils from Three Species of Mentha Cultivated in Romania. Molecules 2017, 22, 263.

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