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Molecules 2017, 22(12), 2237; https://doi.org/10.3390/molecules22122237

Antifungal Activity of Ramulus cinnamomi Explored by 1H-NMR Based Metabolomics Approach

1
Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits & Vegetables, Collaborative Innovation Center of Post-Harvest Key Technology and Quality Safety of Fruits and Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang 330045, China
2
State key laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China
3
Pingxiang University, Pingxiang 337055, China
4
Center for Molecular Metabolism, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing 210014, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 27 November 2017 / Revised: 13 December 2017 / Accepted: 14 December 2017 / Published: 15 December 2017
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Abstract

A 1H nuclear magnetic resonance (NMR)-based approach to metabolomics combined bioassay was used to elucidate the antifungal activity of cinnamaldehyde (the main active compound of Ramulus cinnamomi) isolated from Ramulus cinnamomi (RC). Orthogonal signal correction partial least-squares discriminant analysis (OSC-PLS-DA) of NMR data was constructed to analyze all the P. italicum data acquired from the control and treatment groups at 4, 8, and 12 h. Metabolic profiles disclosed metabolic changes that were related to the antifungal effects of cinnamaldehyde against P. italicum including oxidative stress, disorder of energy metabolism, amino acids, and nucleic acids metabolism in treatment group. This integrated metabolomics approach provided an effective way to detect the antifungal effects of cinnamaldehyde against P. italicum dynamically. View Full-Text
Keywords: metabolomics analysis; Penicillium italicum; antifungal activity; cinnamaldehyde; Ramulus cinnamomi metabolomics analysis; Penicillium italicum; antifungal activity; cinnamaldehyde; Ramulus cinnamomi
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Wan, C.; Li, P.; Chen, C.; Peng, X.; Li, M.; Chen, M.; Wang, J.; Chen, J. Antifungal Activity of Ramulus cinnamomi Explored by 1H-NMR Based Metabolomics Approach. Molecules 2017, 22, 2237.

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