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Molecules 2017, 22(12), 2229; https://doi.org/10.3390/molecules22122229

Synthesis and Biological Activity of 2′,3′-iso-Aryl-abscisic Acid Analogs

1
College of Science, China Agricultural University, Beijing 100193, China
2
College of Agriculture, Shihezi University, Shihezi 832000, China
*
Author to whom correspondence should be addressed.
Received: 25 November 2017 / Revised: 12 December 2017 / Accepted: 14 December 2017 / Published: 15 December 2017
(This article belongs to the Section Medicinal Chemistry)
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Abstract

2′,3′-iso-Benzoabscisic acid (iso-PhABA), an excellent selective abscisic acid (ABA) analog, was developed in our previous work. In order to find its more structure-activity information, some structural modifications were completed in this paper, including the substitution of phenyl ring and replacing the ring with heterocycles. Thus, 16 novel analogs of iso-PhABA were synthesized and screened with three bioassays, Arabidopsis and lettuce seed germination and rice seedling elongation. Some of them, i.e., 2′,3′-iso-pyridoabscisic acid (iso-PyABA) and 2′,3′-iso-franoabscisic acid (iso-FrABA), displayed good bioactivities that closed to iso-PhABA and natural (+)-ABA. Some others, for instance, substituted-iso-PhABA, exhibited certain selectivity to different physiological process when compared to iso-PhABA or (+)-ABA. These analogs not only provided new candidates of ABA-like synthetic plant growth regulators (PGRs) for practical application, but also new potential selective agonist/antagonist for probing the specific function of ABA receptors. View Full-Text
Keywords: abscisic acid; iso-benzoabscisic acid (iso-PhABA); iso-PhABA analogs; ABA like activities abscisic acid; iso-benzoabscisic acid (iso-PhABA); iso-PhABA analogs; ABA like activities
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Wan, C.; Wang, M.; Yang, D.; Han, X.; Che, C.; Ding, S.; Xiao, Y.; Qin, Z. Synthesis and Biological Activity of 2′,3′-iso-Aryl-abscisic Acid Analogs. Molecules 2017, 22, 2229.

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