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Molecules 2017, 22(12), 2101; doi:10.3390/molecules22122101

The Antitumor Constituents from Hedyotis Diffusa Willd

1
College of TCM, Guangdong Pharmaceutical University, No. 280 Outside Loop East Road of Higher Education Mega Center, Panyu District, Guangzhou 510006, China
2
College of Pharmacy, Harbin Medical University-Daqing, Daqing 163319, China
3
Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
*
Authors to whom correspondence should be addressed.
Received: 4 November 2017 / Revised: 18 November 2017 / Accepted: 27 November 2017 / Published: 30 November 2017
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Abstract

As a TCM, Hedyotis diffusa Willd. has been using to treat malignant tumors, and many studies also showed that the extracts from Hedyotis diffusa Willd. possessed evident antitumor activities. Therefore, we carried out chemical study on Hedyotis diffusa Willd. and investigated the cytotoxicity of the obtained compounds on a panel of eight tumor cell lines. As a result, four new compounds were isolated from Hedyotis diffusa Willd., including three iridoid glycosides of Shecaoiridoidside A–C (13) and a cerebroside of shecaocerenoside A (4). Also, six known iridoid compounds (510) were also obtained. The cytotoxicity of all compounds against human tumor cell lines of HL-60, HeLa, HCT15, A459, HepG2, PC-3, CNE-2, and BCG-823 were also evaluated in vitro. New compound 3 exhibited evident cytotoxicity to all tumor cell lines except the Hela, and the IC50 values are from 9.6 µM to 62.2 µM, while new compound 4 showed moderate cytotoxicity to all the cell lines, and the IC50 values are from 33.6 µM to 89.3 µM. By contrast, new compound 1 and known compound 9 showed moderate cytotoxicity to HCT15, A459, and HepG2 selectively. Known compound 7 also exhibited moderate cytotoxicity to HCT15 and A459 selectively. View Full-Text
Keywords: Hedyotis diffusa Willd.; antitumor; iridoid glycosides; cerebrosides Hedyotis diffusa Willd.; antitumor; iridoid glycosides; cerebrosides
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, C.; Zhou, X.; Wang, Y.; Wei, D.; Deng, C.; Xu, X.; Xin, P.; Sun, S. The Antitumor Constituents from Hedyotis Diffusa Willd. Molecules 2017, 22, 2101.

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