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Molecules 2017, 22(12), 2095; doi:10.3390/molecules22122095

Anti-Candida Activity of Bursera morelensis Ramirez Essential Oil and Two Compounds, α-Pinene and γ-Terpinene—An In Vitro Study

1
Laboratorio de Farmacognosia, Unidad de Biología, Tecnología y Prototipos (UBIPRO), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av. de los Barrios No. 1, Los Reyes Iztacala, Tlalnepantla, Edo. de México C.P. 54090, Mexico
2
Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México. Av. de los Barrios No. 1, Los Reyes Iztacala, Tlalnepantla, Edo. de México C.P. 54090, Mexico
3
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán CDMX 04510, Mexico
4
Laboratorio de Bioquímica Molecular, Unidad de Biología, Tecnología y Prototipos (UBIPRO), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México. Av. de los Barrios No. 1, Los Reyes Iztacala, Tlalnepantla, Edo. de México C.P. 54090, Mexico
5
Laboratorio de Fisiología Vegetal, UBIPRO y Laboratorio Nacional en Salud, Facultad de Estudios Superiores-Iztacala UNAM. Av. de los Barrios No. 1, Los Reyes Iztacala, Tlalnepantla, Edo. de México C.P. 54090, Mexico
6
Laboratorio de Microbiología, Unidad de Investigación Multidisciplinaria, Facultad de Estudios Superiores Cuautitlán, Campo 4, Universidad Nacional Autónoma de México, Carretera Cuautitlán-Teoloyucan Km 2.5, San Sebastián Xhala, Cuautitlán Izcalli, Edo. de México C.P. 54700, Mexico
7
Laboratorio de Apoyo a Histología y Biología, Departamento de Ciencias Biológicas, Facultad de Estudios Superiores Cuautitlán, Campo 4, Universidad Nacional Autónoma de México. Carretera Cuautitlán-Teoloyucan Km 2.5, San Sebastián Xhala, Cuautitlán Izcalli, Edo. de México C.P. 54700, Mexico
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Laboratorio de Inmunobiología, Carrera de Medicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Avenida de los Barrios Numero 1, Colonia Los Reyes Iztacala, Tlalnepantla, Edo. de México C.P. 54090, Mexico
*
Author to whom correspondence should be addressed.
Received: 2 November 2017 / Revised: 25 November 2017 / Accepted: 27 November 2017 / Published: 5 December 2017
(This article belongs to the Special Issue Essential Oils as Antimicrobial and Anti-infectious Agents)
View Full-Text   |   Download PDF [2403 KB, uploaded 5 December 2017]   |  

Abstract

The candidiasis caused by C. albicans is a public health problem. The abuse of antifungals has contributed to the development of resistance. B. morelensis has demonstrated antibacterial and antifungal activities. In this work the activity of the essential oil of B. morelensis was evaluated and for its two pure compounds with analysis of the different mechanisms of pathogenesis important for C. albicans. The essential oil was obtained by the hydro-distillation method and analyzed using GC–MS. The anti-Candida activity was compared between to essential oil, α-Pinene and γ-Terpinene. GC–MS of the essential oil demonstrated the presence of 13 compounds. The essential oil showed antifungal activity against four C. albicans strains. The most sensitive strain was C. albicans 14065 (MFC 2.0 mg/mL and MIC50 0.125 mg/mL) with α-Pinene and γ-Terpinene having MFCs of 4.0 and 16.0 mg/mL respectively. The essential oil inhibited the growth of the germ tube in 87.94% (8.0 mg/mL). Furthermore, it was observed that the essential oil diminishes the transcription of the gene INT1. This work provides evidence that confirms the anti-Candida activity of the B. morelensis essential oil and its effect on the growth of the germ tube and transcription of the gene INT1. View Full-Text
Keywords: Bursera morelensis; burseraceae; Candida albicans; α-pinene; γ-terpinene Bursera morelensis; burseraceae; Candida albicans; α-pinene; γ-terpinene
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rivera-Yañez, C.R.; Terrazas, L.I.; Jimenez-Estrada, M.; Campos, J.E.; Flores-Ortiz, C.M.; Hernandez, L.B.; Cruz-Sanchez, T.; Garrido-Fariña, G.I.; Rodriguez-Monroy, M.A.; Canales-Martinez, M.M. Anti-Candida Activity of Bursera morelensis Ramirez Essential Oil and Two Compounds, α-Pinene and γ-Terpinene—An In Vitro Study. Molecules 2017, 22, 2095.

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