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Molecules 2017, 22(12), 2067; doi:10.3390/molecules22122067

A Novel Strategy for Quantitative Analysis of Major Ginsenosides in Panacis Japonici Rhizoma with a Standardized Reference Fraction

1
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
2
College of Biology and Pharmaceutical engineering, Wuhan Polytechnic University, Wuhan 430023, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 1 November 2017 / Revised: 16 November 2017 / Accepted: 23 November 2017 / Published: 27 November 2017
(This article belongs to the Special Issue Current Trends in Ginseng Research)
View Full-Text   |   Download PDF [555 KB, uploaded 27 November 2017]   |  

Abstract

Panacis Japonici Rhizoma (Zhu-Jie-Shen in Chinese), the root of P. japonicus C.A. Mey., is commonly used in traditional Chinese Medicine. Saponins are the major bioactive compounds in this herb. The similarity of polarity and structure of the natural products in herb caused the difficulty of purification and resulted in the shortage and high cost of the reference compounds, which has greatly hindered efforts toward quantification in quality control. A novel strategy using a standardized reference fraction for qualification of the major saponins in Panacis Japonici Rhizoma was proposed to easily and effectively control the quality of PJR. The strategy is feasible and reliable, and the methodology of the developed approach is also validated. The standardized reference fraction was used for quantification, which might solve the shortage of the pure reference compounds in the quality control of herbal medicines. View Full-Text
Keywords: Panax japonicus C. A. Mey.; Panacis Japonici Rhizoma; triterpenoid saponin; ginsenoside; chikusetsusaponin; pseudoginsenoside; standardized reference fraction; quantification; quality control; HPLC Panax japonicus C. A. Mey.; Panacis Japonici Rhizoma; triterpenoid saponin; ginsenoside; chikusetsusaponin; pseudoginsenoside; standardized reference fraction; quantification; quality control; HPLC
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MDPI and ACS Style

Meng, F.-C.; Wu, Q.-S.; Wang, R.; Li, S.-P.; Lin, L.-G.; Chen, P.; Zhang, Q.-W. A Novel Strategy for Quantitative Analysis of Major Ginsenosides in Panacis Japonici Rhizoma with a Standardized Reference Fraction. Molecules 2017, 22, 2067.

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