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Molecules 2017, 22(12), 2000; doi:10.3390/molecules22122000

Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives

1
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China
2
School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China
3
Analysis and Testing Center, Nantong University, Nantong 226019, China
*
Authors to whom correspondence should be addressed.
Received: 9 November 2017 / Revised: 24 November 2017 / Accepted: 24 November 2017 / Published: 27 November 2017
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [734 KB, uploaded 27 November 2017]   |  

Abstract

In this study, in order to find novel biologically active pyrazole oxime derivatives, twenty-eight new pyrazole oxime compounds containing a substituted isoxazole ring were synthesized and evaluated for their acaricidaland insecticidal activities. Bioassays exhibited that some target compounds indicated good acaricidal and insecticidal activities against Tetranychus cinnabarinus, Aphis medicaginis, Mythimna separata, and Nilaparvata lugens. Especially, compounds 9c, 9h, 9u, and 9v showed 100.00%, 90.56%, 90.78%, and 90.62% insecticidal activities against A. medicaginis at the concentration of 20 μg/mL, respectively, compounds 9k and 9u had 70.86% and 100.00% insecticidal activities against M. separata at 20 μg/mL, respectively. View Full-Text
Keywords: isoxazole; pyrazole oxime; synthesis; bioactivity isoxazole; pyrazole oxime; synthesis; bioactivity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dai, H.; Yao, W.; Fang, Y.; Sun, S.; Shi, Y.; Chen, J.; Jiang, G.; Shi, J. Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives. Molecules 2017, 22, 2000.

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