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Molecules 2017, 22(11), 2020; doi:10.3390/molecules22112020

Inkjet Printing of Drug-Loaded Mesoporous Silica Nanoparticles—A Platform for Drug Development

1
Pharmaceutical Sciences Laboratory, Åbo Akademi University, FI-20520 Turku, Finland
2
Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, B-9000 Ghent, Belgium
*
Author to whom correspondence should be addressed.
Received: 9 October 2017 / Revised: 12 November 2017 / Accepted: 17 November 2017 / Published: 21 November 2017
(This article belongs to the Special Issue Mesoporous Silica in Biomedical Applications)
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Abstract

Mesoporous silica nanoparticles (MSNs) have shown great potential in improving drug delivery of poorly water soluble (BCS class II, IV) and poorly permeable (BCS class III, IV) drugs, as well as facilitating successful delivery of unstable compounds. The nanoparticle technology would allow improved treatment by reducing adverse reactions of currently approved drugs and possibly reintroducing previously discarded compounds from the drug development pipeline. This study aims to highlight important aspects in mesoporous silica nanoparticle (MSN) ink formulation development for digital inkjet printing technology and to advice on choosing a method (2D/3D) for nanoparticle print deposit characterization. The results show that both unfunctionalized and polyethyeleneimine (PEI) surface functionalized MSNs, as well as drug-free and drug-loaded MSN–PEI suspensions, can be successfully inkjet-printed. Furthermore, the model BCS class IV drug remained incorporated in the MSNs and the suspension remained physically stable during the processing time and steps. This proof-of-concept study suggests that inkjet printing technology would be a flexible deposition method of pharmaceutical MSN suspensions to generate patterns according to predefined designs. The concept could be utilized as a versatile drug screening platform in the future due to the possibility of accurately depositing controlled volumes of MSN suspensions on various materials. View Full-Text
Keywords: mesoporous silica nanoparticles; digital printing; inkjet printing technology; pharmaceutical nanosuspension; drug delivery; print morphology; screening platform mesoporous silica nanoparticles; digital printing; inkjet printing technology; pharmaceutical nanosuspension; drug delivery; print morphology; screening platform
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wickström, H.; Hilgert, E.; Nyman, J.O.; Desai, D.; Şen Karaman, D.; de Beer, T.; Sandler, N.; Rosenholm, J.M. Inkjet Printing of Drug-Loaded Mesoporous Silica Nanoparticles—A Platform for Drug Development. Molecules 2017, 22, 2020.

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