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Molecules 2017, 22(11), 1993; doi:10.3390/molecules22111993

Polyphenolics from Albizia harveyi Exhibit Antioxidant Activities and Counteract Oxidative Damage and Ultra-Structural Changes of Cryopreserved Bull Semen

1
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
2
Department of Basic Sciences, Faculty of Dentistry, October 6 University, Cairo 12566, Egypt
3
Department of Phytochemistry and Plant Systematics, National Research Center, Dokki, Cairo 12622, Egypt
4
Department of Animal Production, Faculty of Agriculture, Mansoura University, Mansoura 35516, Egypt
5
Animal Production Research Institute, Dokki, Giza 12619, Egypt
*
Authors to whom correspondence should be addressed.
Received: 21 October 2017 / Accepted: 12 November 2017 / Published: 17 November 2017
(This article belongs to the Section Natural Products)
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Abstract

Albizia harveyi is a tropical deciduous tree, found across South and Eastern Africa and widely used in traditional medicine. The leaf extract ameliorated the damaging effects of the frozen-thawing process in cryopreserved bull semen. In a dose-dependent pattern, sperm motility, viability, and membrane integrity were improved compared to the untreated control. Furthermore, the extract increased the percentage of viable sperm cells and reduced the percentages of early apoptotic and apoptotic sperm cells as well as the damage in sperm ultra-structure. These activities are in agreement with the robust antioxidant properties in vitro and in the seminal fluid as observed in the total antioxidant capacity and the lipid peroxidation parameter malondialdehyde. LC-MS yielded 35 compounds. The extract was dominated by quercetin-O-galloyl-hexoside and quercetin-O-pentoside, along with other flavonoid glycosides. The polyphenols are probably responsible for the observed activities. In conclusion, the current findings show that A. harveyi leaves are rich in bioactive polyphenols with functional properties, validating its traditional use. View Full-Text
Keywords: Albizia harveyi; polyphenols; HPLC-PDA-ESI-MS/MS; antioxidant; sperm ultra-structure; cryopreservation Albizia harveyi; polyphenols; HPLC-PDA-ESI-MS/MS; antioxidant; sperm ultra-structure; cryopreservation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sobeh, M.; Hassan, S.A.; El Raey, M.A.; Khalil, W.A.; Hassan, M.A.E.; Wink, M. Polyphenolics from Albizia harveyi Exhibit Antioxidant Activities and Counteract Oxidative Damage and Ultra-Structural Changes of Cryopreserved Bull Semen. Molecules 2017, 22, 1993.

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