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Open AccessCommunication
Molecules 2017, 22(11), 1869; doi:10.3390/molecules22111869

Biophysical Properties and Antiviral Activities of Measles Fusion Protein Derived Peptide Conjugated with 25-Hydroxycholesterol

1
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal
2
Center for Host-Pathogen Interaction, Columbia University Medical Center, 701 W. 168th St., New York, NY 10032, USA
3
Department of Pediatrics, Columbia University Medical Center, 701 W. 168th St., New York, NY 10032, USA
*
Authors to whom correspondence should be addressed.
Received: 13 July 2017 / Accepted: 26 October 2017 / Published: 31 October 2017
(This article belongs to the Special Issue Peptide-Based Drugs and Drug Delivery Systems)
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Abstract

Measles virus (MV) infection is re-emerging, despite the availability of an effective vaccine. The mechanism of MV entry into a target cell relies on coordinated action between the MV hemagglutinin (H) receptor binding protein and the fusion envelope glycoprotein (F) which mediates fusion between the viral and cell membranes. Peptides derived from the C-terminal heptad repeat (HRC) of F can interfere with this process, blocking MV infection. As previously described, biophysical properties of HRC-derived peptides modulate their antiviral potency. In this work, we characterized a MV peptide fusion inhibitor conjugated to 25-hydroxycholesterol (25HC), a cholesterol derivative with intrinsic antiviral activity, and evaluated its interaction with membrane model systems and human blood cells. The peptide (MV View Full-Text
Keywords: measles virus; fusion; peptide; 25-hydroxycholesterol measles virus; fusion; peptide; 25-hydroxycholesterol
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gomes, B.; Santos, N.C.; Porotto, M. Biophysical Properties and Antiviral Activities of Measles Fusion Protein Derived Peptide Conjugated with 25-Hydroxycholesterol. Molecules 2017, 22, 1869.

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