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Molecules 2017, 22(11), 1830; doi:10.3390/molecules22111830

Stenotrophomonas maltophilia: A Gram-Negative Bacterium Useful for Transformations of Flavanone and Chalcone

1
Department of Chemistry, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
2
Department of Biochemistry, Faculty of Biology and Environmental Protection, University of Silesia in Katowice, Jagiellonska 28, 40-032 Katowice, Poland
*
Author to whom correspondence should be addressed.
Received: 3 October 2017 / Accepted: 22 October 2017 / Published: 27 October 2017
(This article belongs to the Section Bioorganic Chemistry)
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Abstract

A group of flavones, isoflavones, flavanones, and chalcones was subjected to small-scale biotransformation studies with the Gram-negative Stenotrophomonas maltophilia KB2 strain in order to evaluate the capability of this strain to transform flavonoid compounds and to investigate the relationship between compound structure and transformation type. The tested strain transformed flavanones and chalcones. The main type of transformation of compounds with a flavanone moiety was central heterocyclic C ring cleavage, leading to chalcone and dihydrochalcone structures, whereas chalcones underwent reduction to dihydrochalcones and cyclisation to a benzo-γ-pyrone moiety. Substrates with a C-2–C-3 double bond (flavones and isoflavones) were not transformed by Stenotrophomonas maltophilia KB2. View Full-Text
Keywords: flavanone; chalcone; dihydrochalcone; biotransformation; Stenotrophomonas maltophilia flavanone; chalcone; dihydrochalcone; biotransformation; Stenotrophomonas maltophilia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kostrzewa-Susłow, E.; Dymarska, M.; Guzik, U.; Wojcieszyńska, D.; Janeczko, T. Stenotrophomonas maltophilia: A Gram-Negative Bacterium Useful for Transformations of Flavanone and Chalcone. Molecules 2017, 22, 1830.

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