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Molecules 2017, 22(11), 1808; doi:10.3390/molecules22111808

A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors

1
Department of Organic Chemistry, Medical University of Lublin, 20-093 Lublin, Poland
2
Institute of Applied Radiation Chemistry, Lodz University of Technology, 90-924 Lodz, Poland
3
Department of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland
*
Authors to whom correspondence should be addressed.
Received: 4 October 2017 / Revised: 19 October 2017 / Accepted: 22 October 2017 / Published: 25 October 2017
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Abstract

Using molecular modeling approach, potential antibacterial agents with triazole core were proposed. A moderate to weak level of antibacterial activity in most of the compounds have been observed, with best minimal inhibitory concentration (MIC) value of 0.003 mg/mL, as shown by the 15 against S. epidermidis. Studied compounds were also submitted to the antifungal assay. The best antifungal activity was detected for 16 with MIC at 0.125 and 0.25 mg/mL against C. albicans and C. parapsilosis, respectively. View Full-Text
Keywords: triazoles; antibacterial activity; molecular modeling triazoles; antibacterial activity; molecular modeling
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Paneth, A.; Frączek, T.; Grzegorczyk, A.; Janowska, D.; Malm, A.; Paneth, P. A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors. Molecules 2017, 22, 1808.

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