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Molecules 2017, 22(10), 1779; doi:10.3390/molecules22101779

Traditional Uses, Origins, Chemistry and Pharmacology of Bombyx batryticatus: A Review

1
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
2
Chengdu Min-Jiang-Yuan Pharmaceutical Co., Ltd., Chengdu 611000, China
3
Key Research Laboratory of Traditional Chinese Medicine Processing Technology, State Administration of Traditional Chinese Medicine of People’s Republic of China, Chengdu 611137, China
*
Authors to whom correspondence should be addressed.
Received: 24 September 2017 / Revised: 16 October 2017 / Accepted: 16 October 2017 / Published: 20 October 2017
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Abstract

Bombyx batryticatus (B. batryticatus), a well-known traditional animal Chinese medicine, has been commonly used in China for thousands of years. The present paper reviewed advances in traditional uses, origin, chemical constituents, pharmacology and toxicity studies of B. batryticatus. The aim of the paper is to provide more comprehensive references for modern B. batryticatus study and application. In Traditional Chinese Medicine (TCM) culture, drugs containing B. batryticatus have been used to treat convulsions, headaches, skin prurigo, scrofula, tonsillitis and fever. Many studies indicate B. batryticatus contains various compounds, including protein and peptides, fatty acids, flavonoids, nucleosides, steroids, coumarin, polysaccharide and others. Numerous investigations also have shown that extracts and compounds from B. batryticatus exert a wide spectrum of pharmacological effects both in vivo and in vitro, including effects on the nervous system, anticoagulant effects, antitumor effects, antibacterial and antifungal effects, antioxidant effects, hypoglycemic effects, as well as other effects. However, further studies should be undertaken to investigate bioactive compounds (especially proteins and peptides), toxic constituents, using forms and the quality evaluation and control of B. batryticatus. Furthermore, it will be interesting to study the mechanism of biological activities and structure-function relationships of bioactive constituents in B. batryticatus. View Full-Text
Keywords: Bombyx batryticatus; traditional uses; origin; chemical constituents; pharmacology; toxicity Bombyx batryticatus; traditional uses; origin; chemical constituents; pharmacology; toxicity
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Hu, M.; Yu, Z.; Wang, J.; Fan, W.; Liu, Y.; Li, J.; Xiao, H.; Li, Y.; Peng, W.; Wu, C. Traditional Uses, Origins, Chemistry and Pharmacology of Bombyx batryticatus: A Review. Molecules 2017, 22, 1779.

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