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Molecules 2017, 22(10), 1746; doi:10.3390/molecules22101746

Pharmacokinetic Comparison of Seven Major Bio-Active Components in Normal and Blood Stasis Rats after Oral Administration of Herb Pair Danggui-Honghua by UPLC-TQ/MS

1
Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China
2
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
3
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
*
Authors to whom correspondence should be addressed.
Received: 13 August 2017 / Revised: 11 October 2017 / Accepted: 12 October 2017 / Published: 17 October 2017
(This article belongs to the Collection Bioactive Compounds)
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Abstract

The compatibility between Danggui (Angelicae Sinensis Radix) and Honghua (Carthami Flos) is a known herb pair, which could activate blood circulation and dissipate blood stasis effects. In this paper, we quantified seven main bio-active components (hydroxysafflor yellow A, caffeic acid, p-coumaric acid, kaempferol-3-O-rutinoside, ferulic acid, 3-n-butylphthalide, and ligustilide) in plasma samples in vivo by UPLC-TQ/MS method and investigatedwhether the pharmacokinetic (PK) behaviors of the seven components could be altered in blood stasis rats after oral administration of the Gui-Hong extracts. It was found that the Cmax and AUC0-t of these components in blood stasis rats had increasing tendency compared with normal rats. Most components in model and normal rats had significant difference in some pharmacokinetic parameters, which indicated that the metabolism enzymes and transporters involved in the metabolism and disposition of these bio-active componentsmay bealtered in blood stasis rats. This study was the first report about the pharmacokinetic investigation between normal and blood stasis rats after oral administrationof Gui-Hong extracts, and these results are important and valuable for better clinical applications of Gui-Hong herb pair and relatedTCM formulae. View Full-Text
Keywords: Danggui; Angelica sinensis; honghua; Carthamus tinctorius; herb pair; pharmacokinetics Danggui; Angelica sinensis; honghua; Carthamus tinctorius; herb pair; pharmacokinetics
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Jin, Y.; Tang, Y.-P.; Zhu, Z.-H.; Shang, E.-X.; Pang, H.-Q.; Shi, X.-Q.; Chen, Y.-Y.; Wang, J.; Chang, X.; Kang, A.; Zhou, G.-S.; Shi, Y.-J.; Sun, J.; Tang, Z.-S.; Li, S.-P.; Duan, J.-A. Pharmacokinetic Comparison of Seven Major Bio-Active Components in Normal and Blood Stasis Rats after Oral Administration of Herb Pair Danggui-Honghua by UPLC-TQ/MS. Molecules 2017, 22, 1746.

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