Design, Synthesis and Antifungal Activity of Psoralen Derivatives
AbstractA series of linear furanocoumarins with different substituents have been designed and synthesized. Their structures were confirmed by 1H-NMR spectroscopy, high resolution mass spectra (EI-MS), IR, and X-ray single-crystal diffraction. All of the target compounds were evaluated in vitro for their antifungal activity against Rhizoctorzia solani, Botrytis cinerea, Alternaria solani, Gibberella zeae, Cucumber anthrax, and Alternaria leaf spot at 100 μg/mL, and some of the designed compounds exhibited potential antifungal activities. Compound 3a (67.9%) exhibited higher activity than the control Osthole (66.1%) against Botrytis cinerea. Furthermore, compound 4b (62.4%) represented equivalent antifungal activity as Osthole (69.5%) against Rhizoctonia solani. The structure-activity relationship (SAR) study demonstrates that linear furanocoumarin moiety has an important effect on the antifungal activity, promoting the idea of the coumarin ring as a framework that might be exploited in the future. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 1950 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Yu, X.; Wen, Y.; Liang, C.-G.; Liu, J.; Ding, Y.-B.; Zhang, W.-H. Design, Synthesis and Antifungal Activity of Psoralen Derivatives. Molecules 2017, 22, 1672.
Yu X, Wen Y, Liang C-G, Liu J, Ding Y-B, Zhang W-H. Design, Synthesis and Antifungal Activity of Psoralen Derivatives. Molecules. 2017; 22(10):1672.Chicago/Turabian Style
Yu, Xiang; Wen, Ya; Liang, Chao-Gen; Liu, Jia; Ding, Yu-Bin; Zhang, Wei-Hua. 2017. "Design, Synthesis and Antifungal Activity of Psoralen Derivatives." Molecules 22, no. 10: 1672.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.