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Molecules 2017, 22(1), 4; doi:10.3390/molecules22010004

Development and Structural Modification of BACE1 Inhibitors

Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China
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Author to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Received: 22 October 2016 / Revised: 13 December 2016 / Accepted: 20 December 2016 / Published: 22 December 2016
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Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder which usually occurs in the elderly. The accumulation of β-amyloid and the formation of neurofibrillary tangles are considered as the main pathogenies of AD. Research suggests that β-secretase 1 (BACE1) plays an important role in the formation of β-amyloid. Discovery of new BACE1 inhibitors has become a significant method to slow down the progression of AD or even cure this kind of disease. This review summarizes the different types and the structural modification of these new BACE1 inhibitors. View Full-Text
Keywords: Alzheimer’s disease; β-amyloid; BACE1; BACE1 inhibitors; structural modification Alzheimer’s disease; β-amyloid; BACE1; BACE1 inhibitors; structural modification
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Gu, T.; Wu, W.-Y.; Dong, Z.-X.; Yu, S.-P.; Sun, Y.; Zhong, Y.; Lu, Y.-T.; Li, N.-G. Development and Structural Modification of BACE1 Inhibitors. Molecules 2017, 22, 4.

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