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Molecules 2017, 22(1), 180; doi:10.3390/molecules22010180

A New Human Cancer Cell Proliferation Inhibition Sesquiterpene, Dryofraterpene A, from Medicinal Plant Dryopteris fragrans (L.) Schott

1
Food Science Department of XiZang Agriculture and Animal Husbandry College, Xizang 860000, China
2
Key Laboratory of Molecular Biology of Heilongjiang Province, College of Life Science, Heilongjiang University, Harbin 150080, China
*
Author to whom correspondence should be addressed.
Academic Editor: John A. Beutler
Received: 29 November 2016 / Revised: 27 December 2016 / Accepted: 16 January 2017 / Published: 21 January 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [977 KB, uploaded 21 January 2017]   |  

Abstract

The global burden of cancer continues to increase largely with the aging and growth of the world population. The purpose of the present work was to find new anticancer molecules from a natural source. We utilized chromatographic methods to isolate compounds from medicinal plant Dryopteris fragrans (L.) Schott. The structure of the new compounds was determined by spectroscopic and spectrometric data (1D NMR, 2D NMR, and EMI-MS). Their anti-proliferation effects against five human cancer cell lines including A549, MCF7, HepG2, HeLa, and PC-3 were evaluated by CCK-8 andlactate dehydrogenase (LDH) assay. A new sesquiterpene, (7S, 10S)-2,3-dihydroxy-calamenene-15-carboxylic acid methyl ester (1), and two known compounds (2 and 3) were isolated. The new sesquiterpene was named dryofraterpene A and significantly inhibited cancer cell proliferation without any obvious necrosis below a 10 μM concentration. In conclusion, a novel anticancer sesquiterpene together with two known compounds was isolated, which might be a promising lead compound for the treatment of cancer. View Full-Text
Keywords: Dryopteris fragrans (L.) Schott; dryofraterpene A; cancer cell; proliferation inhibition Dryopteris fragrans (L.) Schott; dryofraterpene A; cancer cell; proliferation inhibition
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Zhong, Z.-C.; Zhao, D.-D.; Liu, Z.-D.; Jiang, S.; Zhang, Y.-L. A New Human Cancer Cell Proliferation Inhibition Sesquiterpene, Dryofraterpene A, from Medicinal Plant Dryopteris fragrans (L.) Schott. Molecules 2017, 22, 180.

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