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Molecules 2017, 22(1), 164; doi:10.3390/molecules22010164

Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts

1
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Via Ranieri 65, 60100 Ancona, Italy
2
Area de Nutrición y Salud, Universidad Internacional Iberoamericana (UNINI), Campeche C.P. 24040, Mexico
3
Dipartimento di Scienze Agrarie, Alimentari e Ambientali, Università Politecnica delle Marche, 60131 Ancona, Italy
4
Department of Physiology, Institute of Nutrition and Food Technology ‘‘José Mataix”, Biomedical Research Centre, University of Granada, Granada, C.P. 18000, Spain
5
Dipartimento di Scienze Biomediche e Sanità Pubblica, Facoltà di Medicina, Università Politecnica delle Marche, Via Ranieri 65, 60131 Ancona, Italy
6
Centre for Nutrition & Health, Universidad Europea del Atlantico (UEA), 39011 Santander, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 19 December 2016 / Revised: 13 January 2017 / Accepted: 16 January 2017 / Published: 21 January 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2660 KB, uploaded 21 January 2017]   |  

Abstract

A protracted pro-inflammatory state is a major contributing factor in the development, progression and complication of the most common chronic pathologies. Fruit and vegetables represent the main sources of dietary antioxidants and their consumption can be considered an efficient tool to counteract inflammatory states. In this context an evaluation of the protective effects of strawberry extracts on inflammatory stress induced by E. coli LPS on human dermal fibroblast cells was performed in terms of viability assays, ROS and nitrite production and biomarkers of oxidative damage of the main biological macromolecules. The results demonstrated that strawberry extracts exerted an anti-inflammatory effect on LPS-treated cells, through an increase in cell viability, and the reduction of ROS and nitrite levels, and lipid, protein and DNA damage. This work showed for the first time the potential health benefits of strawberry extract against inflammatory and oxidative stress in LPS-treated human dermal fibroblast cells. View Full-Text
Keywords: strawberry; LPS; oxidative stress; inflammation; prevention strawberry; LPS; oxidative stress; inflammation; prevention
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MDPI and ACS Style

Gasparrini, M.; Forbes-Hernandez, T.Y.; Giampieri, F.; Afrin, S.; Mezzetti, B.; Quiles, J.L.; Bompadre, S.; Battino, M. Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts. Molecules 2017, 22, 164.

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