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Molecules 2016, 21(8), 970; doi:10.3390/molecules21080970

Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 23 May 2016 / Revised: 10 July 2016 / Accepted: 21 July 2016 / Published: 25 July 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [559 KB, uploaded 25 July 2016]   |  

Abstract

During our search for interesting bioactive secondary metabolites from mangrove actinomycetes, the strain Streptomyces sp. 219807 which produced a high elaiophylin yield of 4486 mg/L was obtained. A new elaiophylin derivative, halichoblelide D (1), along with seven known analogues 28 was isolated and identified from the culture broth. Their chemical structures were determined by detailed analysis of 1D and 2D NMR and HRMS data. The absolute configuration of halichoblelide D (1) was confirmed by comparing the CD spectrum with those of the reported analogues. Compounds 17 exhibited potent cytotoxic activities against HeLa and MCF-7 cells with IC50 values ranging from 0.19 to 2.12 μM. View Full-Text
Keywords: mangrove actinomycetes; Streptomyces sp. 219807; elaiophylin; cytotoxic mangrove actinomycetes; Streptomyces sp. 219807; elaiophylin; cytotoxic
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MDPI and ACS Style

Han, Y.; Tian, E.; Xu, D.; Ma, M.; Deng, Z.; Hong, K. Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807. Molecules 2016, 21, 970.

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