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Molecules 2016, 21(8), 1060; doi:10.3390/molecules21081060

Efficient Enzyme-Free Biomimetic Sensors for Natural Phenol Detection

1
Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO 74690-970, Brazil
2
Instituto de Química, Universidade Federal de Goiás, Goiânia, GO 74690-970, Brazil
3
Departamento de Farmácia, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG 74690-970, Brazil
4
Departamento de Química Orgánica, Universidad de Cordoba, Cordoba 14014, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Christophe Len
Received: 9 July 2016 / Revised: 4 August 2016 / Accepted: 9 August 2016 / Published: 13 August 2016
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Abstract

The development of sensors and biosensors based on copper enzymes and/or copper oxides for phenol sensing is disclosed in this work. The electrochemical properties were studied by cyclic and differential pulse voltammetry using standard solutions of potassium ferrocyanide, phosphate/acetate buffers and representative natural phenols in a wide pH range (3.0 to 9.0). Among the natural phenols herein investigated, the highest sensitivity was observed for rutin, a powerful antioxidant widespread in functional foods and ubiquitous in the plant kingdom. The calibration curve for rutin performed at optimum pH (7.0) was linear in a broad concentration range, 1 to 120 µM (r = 0.99), showing detection limits of 0.4 µM. The optimized biomimetic sensor was also applied in total phenol determination in natural samples, exhibiting higher stability and sensitivity as well as distinct selectivity for antioxidant compounds. View Full-Text
Keywords: metal oxides; modified electrodes; enzyme-free biosensors; rutin metal oxides; modified electrodes; enzyme-free biosensors; rutin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ferreira Garcia, L.; Ribeiro Souza, A.; Sanz Lobón, G.; dos Santos, W.T.P.; Alecrim, M.F.; Fontes Santiago, M.; de Sotomayor, R.L.Á.; de Souza Gil, E. Efficient Enzyme-Free Biomimetic Sensors for Natural Phenol Detection. Molecules 2016, 21, 1060.

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