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Molecules 2016, 21(8), 1038; doi:10.3390/molecules21081038

Chemo-Enzymatic Synthesis of Oligoglycerol Derivatives

1
Department of Chemistry, University of Delhi, Delhi 110007, India
2
Université de Technologie de Compiègne (UTC), CS 60319, Compiègne Cedex 60203, France
3
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, Berlin 14195, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: Davide Ravelli
Received: 20 July 2016 / Revised: 4 August 2016 / Accepted: 5 August 2016 / Published: 9 August 2016
View Full-Text   |   Download PDF [1448 KB, uploaded 9 August 2016]   |  

Abstract

A cleaner and greener method has been developed and used to synthesize 14 different functionalized oligomer derivatives of glycerol in moderate 29%–39% yields over three steps. After successive regioselective enzymatic acylation of the primary hydroxyl groups, etherification or esterification of the secondary hydroxyl groups and chemoselective enzymatic saponification, the target compounds can efficiently be used as versatile building blocks in organic and supramolecular chemistry. View Full-Text
Keywords: glycerol oligomers; Novozym 435; chemo-enzymatic; regioselectivity; building blocks glycerol oligomers; Novozym 435; chemo-enzymatic; regioselectivity; building blocks
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Singh, A.K.; Nguyen, R.; Galy, N.; Haag, R.; Sharma, S.K.; Len, C. Chemo-Enzymatic Synthesis of Oligoglycerol Derivatives. Molecules 2016, 21, 1038.

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