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Molecules 2016, 21(8), 1059; doi:10.3390/molecules21081059

Punica granatum L. Hydrogel for Wound Care Treatment: From Case Study to Phytomedicine Standardization

1
Programa de Pós-Graduação em Ciências Aplicadas a Produtos Naturais, Universidade Federal Fluminense, Rua Dr. Mario Viana, 523, Santa Rosa, Niterói, RJ, CEP: 24230-540, Brazil
2
Faculdade de Farmácia, Universidade Federal Fluminense, Rua Dr. Mario Viana, 523, Santa Rosa, Niterói, RJ, CEP: 24230-540, Brazil
3
Programa de Pós-Graduação em Engenharia de Biossistemas, Universidade Federal Fluminense, Rua Passo da Pátria, 156, Bloco D, sala 236, São Domingos, Niterói, RJ, CEP: 24210-240, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 2 July 2016 / Revised: 7 August 2016 / Accepted: 7 August 2016 / Published: 22 August 2016
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [3416 KB, uploaded 22 August 2016]   |  

Abstract

The pharmacological activities of many Punica granatum L. components suggest a wide range of clinical applications for the prevention and treatment of diseases where chronic inflammation is believed to play an essential etiologic role. The current work reports a case study analyzing the effect produced by a magistral formulation of ethanolic extracts of Punica granatum peels on a non-healing chronic ulcer. The complete closure of the chronic ulcer that was initially not responsive to standard medical care was observed. A 2% (w/w) P. granatum peels ethanolic extract hydrogel-based formulation (PGHF) was standardized and subjected to physicochemical studies to establish the quality control parameters using, among others, assessment criteria such as optimum appearance, pH range, viscosity and hydrogel disintegration. The stability and quantitative chromatographic data was assessed in storage for six months under two temperature regimes. An efficient HPLC-DAD method was established distinguishing the biomarkers punicalin and punicalagin simultaneously in a single 8 min run. PGHF presented suitable sensorial and physicochemical performance, showing that punicalagin was not significantly affected by storage (p > 0.05). Formulations containing extracts with not less than 0.49% (w/w) total punicalagin might find good use in wound healing therapy. View Full-Text
Keywords: Punica granatum; wound healing; hydrogel; punicalagin; quality control Punica granatum; wound healing; hydrogel; punicalagin; quality control
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fleck, A.; Cabral, P.F.G.; Vieira, F.F.M.; Pinheiro, D.A.; Pereira, C.R.; Santos, W.C.; Machado, T.B. Punica granatum L. Hydrogel for Wound Care Treatment: From Case Study to Phytomedicine Standardization. Molecules 2016, 21, 1059.

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