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Molecules 2016, 21(7), 944; doi:10.3390/molecules21070944

Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis sydowiana and Their 20S Proteasome Inhibitory Activities

1
Key Biosensor Laboratory of Shandong Province, Biology Institute, Shandong Academy of Sciences, Jinan 250014, China
2
National Institute of Biological Resources, Incheon 22689, Korea
3
Duksung IDC, College of Pharmacy, Duksung Women’s University, Seoul 01369, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Fernando Albericio
Received: 9 June 2016 / Revised: 15 July 2016 / Accepted: 18 July 2016 / Published: 20 July 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [356 KB, uploaded 20 July 2016]   |  

Abstract

Fungal endophytes have attracted attention due to their functional diversity. Secondary metabolites produced by Pestalotiopsis sydowiana from a halophyte, Phragmites communis Trinus, were investigated. Eleven compounds, including four penicillide derivatives (14) and seven α-pyrone analogues (510) were isolated from cultures of P. sydowiana. The compounds were identified based on spectroscopic data. The inhibitory activities against the 20S proteasome were evaluated. Compounds 13, 5, and 910 showed modest proteasome inhibition activities, while compound 8 showed strong activity with an IC50 of 1.2 ± 0.3 μM. This is the first study on the secondary metabolites produced by P. sydowiana and their proteasome inhibitory activities. The endophytic fungus P. sydowiana might be a good resource for proteasome inhibitors. View Full-Text
Keywords: Pestalotiopsis sydowiana; secondary metabolites; 20S proteasome inhibitory activities Pestalotiopsis sydowiana; secondary metabolites; 20S proteasome inhibitory activities
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Xia, X.; Kim, S.; Liu, C.; Shim, S.H. Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis sydowiana and Their 20S Proteasome Inhibitory Activities. Molecules 2016, 21, 944.

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