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Molecules 2016, 21(7), 893; doi:10.3390/molecules21070893

Biochemical Constituents and in Vitro Antioxidant and Anticholinesterase Potential of Seeds from Native Korean Persimmon Genotypes

1
School of Applied Biosciences, Kyungpook National University, Daegu 41566, Korea
2
UoN Chair of Oman’s Medicinal Plants & Marine Natural Products, University of Nizwa, Nizwa 616, Oman
3
Department of Agriculture, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan
4
International Institute of Agriculture Research & Development, Kyungpook National University, Daegu 41566, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 26 May 2016 / Revised: 30 June 2016 / Accepted: 1 July 2016 / Published: 8 July 2016
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Abstract

In the current study, the functional and biochemical potential of the seeds of four persimmon cultivars (PC1, PC2, PC3 and PC4) and their role against oxidative stress and acetylcholinesterase (AChE) inhibition were evaluated. In terms of biochemical compositions, free amino acids, fatty acids and organic acids analysis was performed. The free amino acids ranged from 2617.31 (PC2) to 3773.01 μg∙g−1 dry weight (PC4). Oleic acid and linoleic acid were the principal fatty acids, which were significantly higher in PC4 and PC1, respectively. PC4 presented the highest amount of organic acid content (4212 mg∙kg−1), whereas PC2 presented the lowest (2498 mg∙kg−1). PC2 contained higher total phenolic content and flavonoid content, whereas PC3 had the lowest amount as compared to other cultivars. The in vitro DPPH, ABTS and superoxide anion radicals scavenging activity increased in a dose-dependent manner, whereas PC2 showed significantly higher scavenging activities as compared to PC1, PC2 and PC4 types. In the case of AChE inhibition, PC4 showed a moderate activity (67.34% ± 1.8%). In conclusion, the current findings reveal that the studied persimmon seeds cultivars are a source of bioactive natural antioxidants and AChE inhibitors. Such natural products could be employed in pharmaceutical and food industries, whilst can also be considered for the treatment of neurodegenerative diseases such as Alzheimer’s. View Full-Text
Keywords: reactive oxygen species; Alzheimer’s disease; phenolic content; amino acids; fatty acids; human health reactive oxygen species; Alzheimer’s disease; phenolic content; amino acids; fatty acids; human health
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Bilal, S.; Khan, A.L.; Waqas, M.; Shahzad, R.; Kim, I.-D.; Lee, I.-J.; Shin, D.-H. Biochemical Constituents and in Vitro Antioxidant and Anticholinesterase Potential of Seeds from Native Korean Persimmon Genotypes. Molecules 2016, 21, 893.

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