Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells
AbstractProstate cancer is one of the most common malignant tumors in males and it has become a major worldwide public health problem. This study characterizes the encapsulation of Nor-β-lapachone (NβL) in poly(d,l-lactide-co-glycolide) (PLGA) microcapsules and evaluates the cytotoxicity of the resulting drug-loaded system against metastatic prostate cancer cells. The microcapsules presented appropriate morphological features and the presence of drug molecules in the microcapsules was confirmed by different methods. Spherical microcapsules with a size range of 1.03 ± 0.46 μm were produced with an encapsulation efficiency of approximately 19%. Classical molecular dynamics calculations provided an estimate of the typical adsorption energies of NβL on PLGA. Finally, the cytotoxic activity of NβL against PC3M human prostate cancer cells was demonstrated to be significantly enhanced when delivered by PLGA microcapsules in comparison with the free drug. View Full-Text
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Costa, M.P.; Feitosa, A.C.S.; Oliveira, F.C.E.; Cavalcanti, B.C.; da Silva, E.N.; Dias, G.G.; Sales, F.A.M.; Sousa, B.L.; Barroso-Neto, I.L.; Pessoa, C.; Caetano, E.W.S.; Di Fiore, S.; Fischer, R.; Ladeira, L.O.; Freire, V.N. Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells. Molecules 2016, 21, 873.
Costa MP, Feitosa ACS, Oliveira FCE, Cavalcanti BC, da Silva EN, Dias GG, Sales FAM, Sousa BL, Barroso-Neto IL, Pessoa C, Caetano EWS, Di Fiore S, Fischer R, Ladeira LO, Freire VN. Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells. Molecules. 2016; 21(7):873.Chicago/Turabian Style
Costa, Marcilia P.; Feitosa, Anderson C.S.; Oliveira, Fátima C.E.; Cavalcanti, Bruno C.; da Silva, Eufrânio N.; Dias, Gleiston G.; Sales, Francisco A.M.; Sousa, Bruno L.; Barroso-Neto, Ito L.; Pessoa, Cláudia; Caetano, Ewerton W.S.; Di Fiore, Stefano; Fischer, Rainer; Ladeira, Luiz O.; Freire, Valder N. 2016. "Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells." Molecules 21, no. 7: 873.
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