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Molecules 2016, 21(7), 850; doi:10.3390/molecules21070850

Quality Evaluation of Scrophulariae Radix Processed by Different ‘Sweating’ Methods Based on Simultaneous Determination of Multiple Bioactive Constituents Combined with Grey Relational Analysis

1
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
2
Yangzhou Institute for Drug Control, Yangzhou 225100, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 19 May 2016 / Revised: 22 June 2016 / Accepted: 24 June 2016 / Published: 28 June 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1420 KB, uploaded 28 June 2016]   |  

Abstract

Scrophulariae Radix is one of the most popular traditional Chinese medicines (TCMs), which needs to be processed by ‘sweating’ methods. Primary processing of Scrophulariae Radix is an important link which closely relates to the quality of products in this TCM. To facilitate selection of the suitable ‘sweating’ processing method for Scrophulariae Radix, in this study the quality of Scrophulariae Radix processed by different ‘sweating’ methods was evaluated based on simultaneous determination of multiple bioactive constituents combined with grey relational analysis. The contents of iridoid glycosides, phenylpropanoid glycosides, and organic acids in Scrophulariae Radix processed by different ‘sweating’ methods were simultaneously determined using ultra high performance liquid chromatography coupled with triple quadrupole-linear ion trap mass spectrometry (UPLC-QTRAP-MS/MS). Furthermore, grey relational analysis (GRA) was performed to evaluate the ‘sweating’ processed samples according to the contents of twelve constituents. All of the results demonstrated that the quality of Scrophulariae Radix processed by oven drying at 35 °C and ‘sweating’ for three days was better. The developed method was useful for the overall assessment on quality of Scrophulariae Radix, and this study may provide the foundation and support for ‘sweating’ processing of Scrophulariae Radix in normalization and standardization. View Full-Text
Keywords: Scrophulariae Radix; ‘sweating’; UPLC-QTRAP-MS/MS; simultaneous determination; grey relational analysis Scrophulariae Radix; ‘sweating’; UPLC-QTRAP-MS/MS; simultaneous determination; grey relational analysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, S.; Hua, Y.; Xu, L.; Zou, L.; Liu, X.; Luo, Y.; Liu, J.; Yan, Y. Quality Evaluation of Scrophulariae Radix Processed by Different ‘Sweating’ Methods Based on Simultaneous Determination of Multiple Bioactive Constituents Combined with Grey Relational Analysis. Molecules 2016, 21, 850.

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