Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents
AbstractAs bacterial biofilms are often refractory to conventional antimicrobials, the need for alternative and/or novel strategies for the treatment of biofilm related infections has become of paramount importance. Herein, we report the synthesis of novel hybrid molecules comprised of two different hindered nitroxides linked to the piperazinyl secondary amine of ciprofloxacin via a tertiary amine linker achieved utilising reductive amination. The corresponding methoxyamine derivatives were prepared alongside their radical-containing counterparts as controls. Subsequent biological evaluation of the hybrid compounds on preformed P. aeruginosa flow cell biofilms divulged significant dispersal and eradication abilities for ciprofloxacin-nitroxide hybrid compound 10 (up to 95% eradication of mature biofilms at 40 μM). Importantly, these hybrids represent the first dual-action antimicrobial-nitroxide agents, which harness the dispersal properties of the nitroxide moiety to circumvent the well-known resistance of biofilms to treatment with antimicrobial agents. View Full-Text
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Verderosa, A.D.; Mansour, S.C.; de la Fuente-Núñez, C.; Hancock, R.E.W.; Fairfull-Smith, K.E. Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents. Molecules 2016, 21, 841.
Verderosa AD, Mansour SC, de la Fuente-Núñez C, Hancock REW, Fairfull-Smith KE. Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents. Molecules. 2016; 21(7):841.Chicago/Turabian Style
Verderosa, Anthony D.; Mansour, Sarah C.; de la Fuente-Núñez, César; Hancock, Robert E.W.; Fairfull-Smith, Kathryn E. 2016. "Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents." Molecules 21, no. 7: 841.
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