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Molecules 2016, 21(7), 820; doi:10.3390/molecules21070820

Justicidin B: A Promising Bioactive Lignan

1
Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, P. O. Box 71345-1583 Shiraz, Iran
2
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, P. O. Box 71345-3119 Shiraz, Iran
3
Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, P. O. Box 71345-1583 Shiraz, Iran
Dedicated to Professor Dr. August Wilhelm Alfermann on the Occasion of His 74th Birthday.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 29 May 2016 / Revised: 18 June 2016 / Accepted: 21 June 2016 / Published: 23 June 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1182 KB, uploaded 23 June 2016]   |  

Abstract

Adverse effects and drug resistance to the current onchopharmacologicals have increased the demand for alternative novel therapeutics. We herein introduce justicidin B, an arylnaphthalen lignan isolated from different plant origins, especially Justicia, Phyllanthus, Haplophyllum and Linum species. This cyclolignan exhibits a wide array of biological properties ranges from piscicidal to antifungal, antiviral and antibacterial activities. Activity against Trypanosoma brucei makes justicidin B a potential antiprotozoal agent for the treatment of neglected tropical diseases. Pharmacological properties like antiplatelet, anti-inflammatory and bone resorption inhibition have been also attributed to justicidin B. This compound is a potent cytotoxic substance on several cell lines, especially chronic myeloid and chronic lymphoid leukemia. Pharmacological values, natural variation, as well as biotechnological production of justicidin B by plant cell, tissue and organ culture are also described in this review. Chemical characteristics and chromatographic methods to identify justicidin B and its biosynthetic pathway have been discussed. Different approaches to the total synthesis of justicidin B are compared. This review would shed light on the role of justicidin B as an intriguing natural compound and provides a chance to optimize conditions for industrial applications. View Full-Text
Keywords: lignan; arylnaphthalene; justicidin B; distribution; chemistry; biosynthesis; biotechnological production; biological activity; synthesis; chromatography lignan; arylnaphthalene; justicidin B; distribution; chemistry; biosynthesis; biotechnological production; biological activity; synthesis; chromatography
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hemmati, S.; Seradj, H. Justicidin B: A Promising Bioactive Lignan. Molecules 2016, 21, 820.

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