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Molecules 2016, 21(6), 807; doi:10.3390/molecules21060807

Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders

1
Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria
2
Department of Pharmaceutical Botany, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
3
Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic
4
Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria
5
Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 1 April 2016 / Revised: 9 June 2016 / Accepted: 13 June 2016 / Published: 22 June 2016
(This article belongs to the Special Issue Effects of Natural Products in the Context of Cardiometabolic Disease)
View Full-Text   |   Download PDF [1020 KB, uploaded 22 June 2016]   |  

Abstract

Natural products have always been exploited to promote health and served as a valuable source for the discovery of new drugs. In this review, the great potential of natural compounds and medicinal plants for the treatment or prevention of cardiovascular and metabolic disorders, global health problems with rising prevalence, is addressed. Special emphasis is laid on natural products for which efficacy and safety have already been proven and which are in clinical trials, as well as on plants used in traditional medicine. Potential benefits from certain dietary habits and dietary constituents, as well as common molecular targets of natural products, are also briefly discussed. A glimpse at the history of statins and biguanides, two prominent representatives of natural products (or their derivatives) in the fight against metabolic disease, is also included. The present review aims to serve as an “opening” of this special issue of Molecules, presenting key historical developments, recent advances, and future perspectives outlining the potential of natural products for prevention or therapy of cardiovascular and metabolic disease. View Full-Text
Keywords: natural products; cardiovascular disease; metabolic disorders; diabetes mellitus; statins; biguanides; dietary constituents; coffee; molecular targets natural products; cardiovascular disease; metabolic disorders; diabetes mellitus; statins; biguanides; dietary constituents; coffee; molecular targets
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Waltenberger, B.; Mocan, A.; Šmejkal, K.; Heiss, E.H.; Atanasov, A.G. Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders. Molecules 2016, 21, 807.

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